Health
Financing talks for production of potential Scottish Covid-19 vaccine
Professional vaccine companies are seeking subsidies to increase production of potential vaccinations against Covid-19 from Scottish laboratories.
Headquartered in France, Valneva is working with the US-listed Dynavax to develop a vaccine candidate for the coronavirus pandemic and is in discussions with the Epidemics and Innovation Alliance (CEPI). The project is currently in preclinical stage stage, But we plan to reach clinical trials by the end of the year.
Valneva has 500 employees in six countries and the Scottish facility in Livingston has approximately 100 staff. They are entrusted with producing a “seed virus” that has come to study French and Austrian colleagues working on the development of vaccine candidates.
David Lawrence, Scotland-based Chief Financial Officer of Barneva, said the new candidate is based on an approved vaccine against another disease currently being produced in Livingston. A successful collaboration with Dynavax will also produce the drug substance for the Covid-19 vaccine. Scotland..
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“We initially think we can take 30 to 50 million doses (in a year) in Livingstone, and then we can scale up,” says Lawrence. “The number depends on the size of the dose and the dosing schedule. Whether one or two injections are needed, or more boosters.”
Listed on Euronext and the Vienna Stock Exchange, Valneva has owned a Scottish facility since 2005. Previously he was a contract supplier to a French company that took over the business after going bankrupt.
Dynavax offers the CpG 1018 adjuvant, which is already used in a vaccine against adult hepatitis B that has been approved by the US Food and Drug Administration (FDA). An adjuvant is added to the vaccine to enhance the immune response, producing more antibody and longer lasting immunity.
It is combined with Valneva’s IXIARO platform, a commercial vaccine product for vaccination to prevent Japanese encephalitis. Both IXIARO and VLA1553 (Valneva’s vaccine against the Chikungunya virus) are produced in Livingston.
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Lawrence said cooperating partners believe that combining proven approaches is the best option for rapidly developing safe and effective vaccines against Covid-19.
Their candidates will not be live virus vaccines. Coronavirus It is used to stimulate a response from the immune system. Their inactivated vaccine does not have the ability to cause the disease, making it a safer alternative for high-risk groups such as the elderly, people with compromised immune systems, and individuals afflicted with other diseases.
“We believe there is room to bring inactivated vaccines to the market even if another solution comes out,” he said.
Valneva has previously worked with CEPI on the Chikungunya vaccine, but Lawrence said he provided a “good template” for discussions about funding Covid-19 vaccine candidates.
CEPI is an international non-profit organization founded in 2017. finance Coordinate the development of new medical measures to prevent and contain infectious diseases. It was founded by the Governments of Norway, Germany, Japan and India, along with Bill, Melinda Gates Foundation and Welcome Trust.
CEPI has invested in developing six vaccine candidates against Covid-19. This includes a record $ 388m (£ 314m) of funding announced earlier this week to US-based Novavax.
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