Rendicivir vs Favipiravir and Other Covid-19 Reusable Drugs | Pune News

India needs to urgently decide on a course of medicine for Covid-19 treatment. The virus is about to stay, at least in the short term. The vaccine is also for a while.
There are at least 50 types of drugs, from HIV protease inhibitors to antiviral drugs, ACE inhibitors, anti-inflammatory drugs, pneumonia, respiratory, malaria, tuberculosis, arthritis, leprosy, alcoholism, immunomodulators, antidiarrheals ..
However, the Indian Medical Research Council has approved a fixed dose combination (FDC) of lopinavir-ritonavir, first prescribed for the treatment of HIV / AIDS for Covid-19 patients. Drug conversion and FDC clinical studies include trials of optimal doses for a limited number of patient cohorts. When time is important, the drug dose and efficacy of recycled drug, and side effects are clearly known. These drugs also have the advantage of being generally unpatented (old drugs) and are already manufactured by generic drug companies in India. The Drug Transfer Task Force has ranked favipiravir and tocilizumab as the most promising for combating this disease.
The new arrival in the therapeutic arsenal is the RNA polymerase inhibitor rendecivir. Stop coronavirus replication. Gilead Sciences of the United States discovered rendecibir to combat the 2014 African Ebola virus outbreak. It is now reviving this molecule through accelerated solidarity clinical trials.
Gilead holds the Rendecibir patent right granted by the Indian Patent Office on February 18, this year. The manufacture and sale of Lemedesibir requires the terms to be negotiated between the Indian pharmaceutical company and Gilead. Significant observations by the National Institute of Allergy and Infectious Diseases (NIAID) and the US Food and Drug Administration (US-FDA) show that rendecibir shortens recovery from 15 to 11 days and improves mortality from 11.6% to 8% It is possible. Rendescivir is given intravenously. This means the patient needs to be in the hospital.
Fabipiravir, a purine nucleic acid analog, is a potent RNA-dependent RNA polymerase inhibitor approved for use in influenza. Both “viruses” work by a similar RNA virus cell killing mechanism. Several Indian companies, including the Scientific and Industrial Research Council (CSIR), have been licensed for clinical trials in favipiravir.
Published results of a favipiravir clinical study showed that out of 80 patients, 35 drug-treated significantly reduced viral clearance time compared to 45 in the control arm (yes Patients who did not) -11 also had a 7-day clinical recovery rate increased from 55.86% to 71.43% in the median drug group with 4-day recovery.
Fabipiravir is a bioavailable tablet marketed by Fujifilm in Japan as Avigan. A patent was filed in India around 2000, and the manufacturing process for economical production is almost complete. The molecular complexity of Rendescivir (formula: C27 H35 N6 O8 P) is due to its chirality or one-handedness, as well as its difficulty of synthesis and manufacturing process favipiravir (C5 H4 F N3 O2). Rendescivir is a new drug with its synthetic pathway and currently unoptimized scale-up.
Favipiravir may be an affordable COVID-19 drug with favorable results in human clinical trials.
The writer is a director of CSIR-National Chemical Laboratory in Pune and a senior professor of chemistry at Central University of Hyderabad. The expressed views are personal

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos