Health
How does the Omicron variant challenge the treatment of COVID-19?
The treatment that COVID-19 patients can receive with tablets to avoid life-threatening illnesses has been like a holy grail for doctors and pharmaceutical companies.
The earliest treatments that have been shown to be useful have usually been given via blood transfusions or to patients who have become ill enough to require hospitalization.
Two years after the first case of COVID-19 was reported in China, two pill-based therapies emerged, and even skeptical scientists are welcomed as potential game changers.
Targeted at newly infected patients at risk of developing severe illness, the drug promises to reduce hospitalizations and deaths and reduce the likelihood that users will spread the coronavirus.
Research is underway to determine how well these and other therapies work against the omicron variants of the virus identified in late November.
What is the new medicine?
Pfizer’s first oral treatment, Paxrovid, is a combination of two antivirals. One is designed to block the action of the major enzymes that the coronavirus uses to make copies of itself. The other is the HIV drug ritonavir, which helps delay the breakdown of the first drug and allows it to remain active in the body longer and at higher concentrations.
Second treatment, MolnupiravirA product of Merck & Co and Ridgeback Biotherapeutics, originally developed to treat influenza. Pills inhibit coronavirus replication by a mechanism known as lethal mutagenesis.
Simply put, it makes mistakes in the machine that replicates the genetic material of the virus, thereby impairing the copy.
How effective are they?
Paxlovid Reduces the risk of hospitalization or death for high-risk COVID-19 patients by 89%, According to an interim analysis of the trial reported by Pfizer on November 5.
The results were the same even if treatment was started within 3 or 5 days of the onset of symptoms.
Molnupiravir was found to reduce the chances of hospitalization or death by 30% in a study of adults at high risk of severe COVID-19, Merck and Ridgeback reported on November 26.
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Sources 2/ https://www.channelnewsasia.com/world/covid-19-coronavirus-omicron-variant-treatment-2370956 The mention sources can contact us to remove/changing this article |
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