New Zealand is one step closer to producing its own mRNA vaccine

Timaru’s biotechnology company and its research partners are one step closer to New Zealand, which manufactures its own mRNA vaccine after the arrival of New Zealand’s first $ 1 million machine.

Dr. Megan Woods, Minister of Research and Science Innovation, said it was “great” to see government investment and research communities and the industrial sector come together to take the opportunity when the machine goes on sale at Washdike’s South Pacific Serra on Thursday. Said. For New Zealand.

“It’s satisfying and exciting,” Wood said.

“It’s great to see. It’s no surprise that this is in Timaru. [the machine].. South Pacific Cera has built its core strength in animal vaccines. New Zealand has amazing vaccination capabilities and is a world leader in animal vaccination. “

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The machine is funded by a private donor to the Malaghan Institute of Medical Research, a biomedical laboratory that is part of the New Zealand Vaccine Alliance Aotearoa – Ohu Kaupare Huaketo (Vaanz).

South Pacific Serra is part of its consortium, working with laboratories, the University of Otago, the University of Victoria, Avalia Immunotherapy, ESR, AgResearch, and many local and international collaborators to research and develop the Covid vaccine. doing. New Zealand and the Pacific Ocean.

This machine, called NanoAssembler Blaze, is used to generate lipid nanoparticles (fine fat globules) to protect mRNA (messenger ribonucleic acid), a genetic material used in vaccines, clinical medicine, and research. ..

In the case of the Pfizer Covid-19 vaccine, mRNA is a genetic substance that tricks the body into making the viral protein itself. This, in turn, helps develop antibodies to fight the virus when the immune system encounters it again.

Because mRNA is fragile, lipid nanoparticles prevent it from being destroyed when it is placed in a cell and unloaded.

Dr. William Rolleston, co-founder and co-director of South Pacific Sera, said the machine added new features to the company’s Good Manufacturing Practices (GMP) vaccine manufacturing infrastructure.

“The Covid-19 vaccine is just the tip of the iceberg that this technology offers, and has great potential for therapeutic development not only in human medicine, but across major sectors,” said Roleston.

The arrival of this technology marks an important step for New Zealand to produce its own mRNA vaccines and other RNA treatments in the future, said the director of the Malagan Institute and Professor Graham Le Gros of the Burns Program. rice field.

“Blaze makes it possible to bridge the gap between laboratory research and clinical development,” said Le Gross.

“This is just the beginning of the envisioned RNA nanomedicine pipeline in New Zealand. It is about transforming mRNA and RNA research and development into homemade vaccines and therapies.”

He said it could provide New Zealand with a platform for vaccine safety and provide a rapid response to future pandemics.

The first job of the machine is the pilot mRNA Covid-19 vaccine being developed by Vaanz.

Le Gros said the purpose of Vaanz is to incorporate the vaccine into human clinical trials and “to inform how to develop regional capabilities and build New Zealand’s mRNA infrastructure.”

Mayor Nigel Bowen of the Timaru district, who participated in the launch, said it demonstrates Timaru’s regional capabilities.

“It’s great to be at the forefront of research and development. It’s also a victory for Timaru.”

of November 2021 South Pacific Sera has agreed to manufacture a Covid-19 test kit for Auckland’s diagnostic biotechnology company Pictor...

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