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Tuberculosis can cause premature cellular senescence, new research discovers

Tuberculosis can cause premature cellular senescence, new research discovers
Tuberculosis can cause premature cellular senescence, new research discovers

 


India reported 19,33,381 cases of new and recurrent TB in 2021 — an increase of 19% year-on-year — the Center stated in its annual TB report.

Human and animal cells that recovered prematurely from tuberculosis to the age of 12-14 years were discovered in a new study. According to a Baylor College of Medicine study, survivors are at increased risk of relapse and death, even after successful treatment.

Premature cellular senescence may be the reason for the high risk of death for tuberculosis survivors. Asian News International Dr. Andrew Dinaldo, an assistant professor of infectious diseases at Baylor College of Medicine, said:

Research published in aging, Measured cell aging. Researchers have also focused on the epigenetic clock of cells.

Epigenetics examines how a cell’s DNA is coiled. How DNA is coiled inside the cell changes with age, and severe infections change it and increase premature aging.

Read again | World Tuberculosis Day: Lung Health Should Stay High on the Post-Covid World Agenda

In this study, researchers studied several cohorts and multiple tissue types. They found that tuberculosis induces perturbations in epigenetic regulation, especially those mediated by DNA methylation. These changes are associated with oxidative stress-induced aging and correlate with premature cell aging. Both guinea pigs and humans have preserved these processes.

Dr. Dinaldo, the lead author of the study, said this is an important area of ​​note after severe infections such as SARS-CoV-2 and sepsis. He said the severity of the infection is also involved in cellular senescence.

Dr. Christian Koafa, an associate professor of molecular cell biology at Baylor College of Medicine and the corresponding author, aims to delay and reduce premature epigenetic aging of these cells as the mechanism is elucidated. I mentioned that there are several ways to do this.

Read again | World Tuberculosis Day 2022: History, Themes, Importance

India reported 19,33,381 cases of new and recurrent tuberculosis in 2021 — an increase of 19% year-on-year — the Center stated in its annual tuberculosis report released Thursday by Federal Minister of Health Mansukh Mandaviya.

According to a report released on World Tuberculosis Day, there are an estimated Rs. 49,300 deaths excluding HIV patients from infectious diseases in 2020, which is 13% higher than the previous year.

India reports more than 26% of the highest cases in the world. It also reports 34% of deaths from bacterial infections.

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