Health
SARS-CoV-2 can spread via intercellular infections | TS Digest
Editor’s Choice in Microbiology
The virus normally spreads to the host cell as virions, which are particles containing a cargo of genetic material wrapped in a protein shell. In addition to this so-called cell-free infection, some viruses spread genetic material by hopping directly from one cell to another via tight junctions, virological synapses, or other mechanisms. You can also. This is a more efficient route to circumvent the host’s immune defense.
Shan-Lu Liu and colleagues at The Ohio State University set out to see if this intercellular transmission occurs in SARS-CoV-2. The team designed a pseudoviral genome to contain the genes for peplomer and fluorescent proteins, and tracked virus movement in two cultures. One is where the cells come into contact and the other is where the cells are physically separated. Neither condition prevented cell-free infection, but only the first allowed intercellular infection.
look “What the pseudovirus brings to the study of SARS-CoV-2“
The results show that about 90% of viral infections were between cells, probably due to the fusion of adjacent infected and uninfected cells, Liu said. Further in vitro experiments combining genuine SARS-CoV-2 with serum samples from people who received the antiviral drug remdecibyl or mRNA vaccine showed that cell-to-cell infections were neutralized by the virus with drugs or antibodies. Suggested to help prevent. This ability to spread without leaving the intracellular environment can help “lead to persistent or long-term infections,” Liu said.
Clare Jolly, a virologist at University College London who was not involved in the study, states that Liu’s team offers excellent evidence of cell-cell transmission. It’s not very clear how much this happens in vivo, or whether it’s the result of cell-cell fusion, she said, and that other viruses usually use different tactics. “Is it really real? [SARS-CoV-2] What the virus does with primary epithelial cells is an open question. “
Liu says his lab is currently digging into the mechanics and is expanding the work to be explored as current research focuses on SARS-CoV-2 alpha and beta mutants. Omicron..
C. Zeng et al. , “SARS-CoV-2 spreads through cell-to-cell transmission” PNAS119: e2111400119, 2022.
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Sources 2/ https://www.the-scientist.com/the-literature/sars-cov-2-can-spread-via-cell-to-cell-transmission-69804 The mention sources can contact us to remove/changing this article |
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