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Studies Reveal A Large Collection of Genes Behind Schizophrenia-Consumer Health News
Thursday, April 7, 2022 (HealthDay News)-Researchers who have identified 120 genes associated with schizophrenia find their findings the strongest in history to show the genetic basis of mental illness, leading to new therapies. It states that there is a possibility.
“Previous studies have shown an association between schizophrenia and many anonymous DNA sequences, but we rarely associated findings with specific genes,” Cardiff University Psychiatry and Clinical Neuroscience. Michael O’Donovan, co-lead author of the division, said. In Wales.
“This study not only significantly increased the number of these associations, but also associated many of them with specific genes, which helped us understand the cause of this disorder and identify new therapies. It’s a necessary step on a difficult road to do. “He added.
In the biggest genetic study of schizophreniaHundreds of researchers in 45 countries have analyzed the DNA of nearly 77,000 people in this condition and nearly 244,000 people without this condition.
In addition to identifying 120 genes that may contribute to schizophrenia, researchers have concentrated these genes in brain cells called neurons, but in other cell and tissue types. I found that it wasn’t.
This suggests that neurons play an important role in schizophrenia, according to the authors of a study published in the journal on April 6. Nature..
They also stated that the abnormal neuronal function of schizophrenia affects many areas of the brain and can explain its wide range of symptoms, including hallucinations, delusions, and thought problems.
“People with schizophrenia can recover, but many do not respond well to treatment, experience long-term problems with their mental and physical health, and become involved in relationships, education, and work. I also experience the impact, “said co-author James Walters Cardiff University’s MRC Center for Neuropsychiatric Genetics and Genomics.
He said researchers hope that their discoveries and the discoveries of companion studies can be used to advance understanding. schizophrenia And the development of “fundamentally new” treatments.
“But these processes are often not simple and require a lot of work by other neuroscientists to translate genetic findings into a detailed understanding of the disease mechanism,” Walters added in a news release. I did.
For more information
For schizophrenia, National Center of Neurology and Psychiatry..
Source: Cardiff University, News Release, April 6, 2022
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