Health
Asthma drugs have been found to be effective against COVID-19.The mechanism is as follows
Bangalore researchers at the Indian Institute of Science (IISc) reduce the replication of the COVID-19-causing virus SARS-CoV-2 in human immune cells by Montelukast, a drug used in asthma. Revealed that it can be done. Used to reduce inflammation and ease breathing in asthma patients, this drug has been shown to be effective against the coronavirus.
“SARS-CoV-2, the causative agent of the pandemic of severe coronavirus disease (COVID-19), is a virus containing encapsulated positive-strand RNA and belongs to the beta coronavirus family,” the eLife Journal said. According to the research done.
The study points out that the drug binds strongly to one end of SARS-CoV-2Nsp1, one of the first viral proteins released in human cells. This protein binds to the ribosomes of the protein-producing mechanism in immune cells, stopping the synthesis of important proteins required by the immune system, thereby weakening the immune system.
In addition, he states: “Montelukast’s rescue of the arrest of host protein synthesis seems to contribute to the antiviral activity of the drug, but further experiments are essential to elucidate the detailed mechanism of its antiviral activity.”
Researchers have checked over 1,600 US FDA-approved drugs to find one that binds strongly to Nsp1 using computational modeling. They nominated drugs such as Montelukast and the anti-HIV drug saquinavir to understand the stability of Nsp1. The team cultured human cells that produced Nsp1 in the lab and treated them separately with montelukast and saquinavir.
In a statement, Assistant Professor Tanweer Hussain of the Department of Molecular Regeneration said: The antiretroviral drug (saquinavir) showed good affinity, but not stability. On the other hand, it was found that monetrucast binds strongly and stably to Nsp1 and allows the host cell to resume normal protein synthesis. “
Read again: The Covid-19 vaccine still works, but researchers are looking for new improvements
Read again: COVID-19: 85% of fresh cases of Haryana from Gurgaon alone
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Sources 2/ https://www.businesstoday.in/coronavirus/story/asthma-drug-found-effective-against-covid-19-heres-how-it-works-331237-2022-04-26 The mention sources can contact us to remove/changing this article |
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