Lifestyle factors are important even at high genetic risk for Alzheimer’s disease

American Heart Association Midlife Score Simple7 of life -Evaluation of physical activity, diet, obesity, smoking, blood pressure, cholesterol, and blood glucose levels-were associated with a risk of dementia in later years, even in people at high genetic risk for Alzheimer’s disease.

A higher middle-aged score for Life’s Simple 7, an indicator of cardiovascular and brain health across the genetic risk profile, is an analysis of data from atherosclerosis risk in the community, reducing the incidence of dementia. Was mainly related to (ARIC) Shown by the cohort.

Dr. Adriantin of the Mississippi Medical College found that European-American study participants were consistently associated with people at highest genetic risk (HR 0.92 per point on Life’s Simple 7 score, 95% CI 0.88-0.96). I reported that I was doing it. Jackson Center, and co-author.

For African-American participants, the association followed a similar pattern, but was not statistically significant, had wide confidence intervals, and had a small sample size, limiting reliable reasoning. Neurology..

“It is known that the higher the Life’s Simple 7 score, the better the brain health of the general population, but it is unclear whether this protective association can be observed among people at high genetic risk. “Tin said. Today’s MedPage..

“Our study found that higher Life Simple 7 scores were associated with a lower risk of dementia across the range of genetic risk,” she added. “Our study found that 30 years of follow-up data showed that the higher the middle-aged score, the lower the risk of dementia, so maintaining a high Life’s Simple 7 score early in life is not possible. Especially advantageous. “

This study followed 11,561 people in the ARIC cohort for the development of dementia for a median of 26.2 years. This includes 8,823 Europeans and 2,738 Africans. The average age of participants at baseline was 54 years.

Life’s Simple 7 scores range from 0 to 14, with 14 representing the healthiest lifestyle. The average baseline score was 8.3 for European Americans and 6.6 for African Americans.

Gene risk scores were generated using data from genome-wide association studies of Alzheimer’s disease. The highest genetic risk group had at least one copy of the risk variant for Alzheimer’s disease. APOE4, It was found in 27.9% of European Americans and 40.4% of African Americans in the study.

During the course of the study, 1,603 European Americans and 631 African Americans developed dementia. A higher Life Simple7 score was associated with a lower risk of dementia in both groups.

For European Americans, Life’s Simple 7 mid-scores (7 or 8) and high scores (9-14) were associated with a 30% and 43% lower risk of dementia, respectively, compared to lower scores. rice field(P<0.001). HigherLife's Simple 7 score was also associated with a pattern of reduced risk of dementia in African Americans, but the sample size was small and the findings were not statistically significant.

“The wide range of presumed confidence intervals among African-American participants limits their interpretation and emphasizes the need for larger sample-size studies among African-American individuals,” Tin said. The co-author said.

The researchers pointed out that the study had some limitations. Gene risk scores were generated based on a genome-wide association study of Alzheimer’s disease, which resulted in the use of dementia of all causes. In addition, Life’s Simple 7 score was obtained once at baseline, so researchers were unable to assess the impact of longitudinal changes on the development of dementia.