Health
A study on the eradication of rectal cancer in all patients by immunotherapy by the Memorial Sloan Kettering Cancer Center
Sascha Roth remembers a phone call on a busy Friday night.
She ran around her home in Washington, DC, packing her luggage for New York. In New York, she was scheduled to receive radiation therapy for rectal cancer for several weeks.
However, a call from medical oncologist Andrea Selsek of the Memorial Sloan Kettering Cancer Center changed everything, leaving her “surprised and ecstatic-I was very happy.”
Dr. Sersek said her latest tests showed evidence of cancer in Sasha, who was 38 at the time, after Sasha was treated for six months as the first patient in a clinical trial that included immunotherapy with MSK. He said he didn’t.
Immunotherapy uses the body’s own immune system as an ally against cancer. The MSK clinical trial was the first to investigate whether immunotherapy alone could defeat rectal cancer that did not metastasize to other tissues in a subset of patients whose tumors contained specific genetic mutations. ..
“Dr. Cercek told me that a team of doctors examined my exam,” Sascha recalls. “And they couldn’t find any signs of cancer, so Dr. Cercek said there was no reason to make me tolerate radiation therapy.”
These same notable results are repeated in all 14 MSK clinical trials for rectal cancer with specific mutations.
According to the hospital, it’s a small trial so far, but the results are so impressive that it was published in the New England Journal of Medicine and featured in June 2022 at the country’s largest gathering of clinical oncologists. ..
In each case, rectal cancer disappeared after immunotherapy without the need for standard radiation, surgery, or chemotherapy, and the cancer recurred in any of the patients who had not had cancer for up to 2 years. not.
“It’s incredibly rewarding,” says Dr. Cercek. He can lose to radiation and surgery. “
As the first patient to enroll in the trial, the research team was worried that Sascha’s experience would turn out to be outliers. Sascha explains: “Before I came to MSK, an oncologist at another medical center told me that I needed chemotherapy, radiation therapy, and surgery. Instead, I infused immunotherapy every few weeks in New York and had no side effects. Seemed easy in comparison. “
It turns out that Sascha was no exception. Dr. Luis Diaz said, “The first patient responded completely to the treatment and did not need anything else. The second patient did not require surgery or radiation. The third patient. Is the 10th patient who responded completely immediately. That’s amazing. “
Of course, the patient was even more excited. “A young man and his family were just sitting in a stunned silence when I told them that his cancer had disappeared,” recalls Dr. Cercek. “Then they thanked us many times.” She went on to ask, “A young woman looked at the screen during the examination and asked,’Where is the tumor?'” It’s gone. ” We told her. “
Dr. Selsek said: “The most exciting part of this is that each and every patient needs only immunotherapy. We don’t radiate and no one has surgery,” she continues. “They maintained normal bowel function, bladder function, sexual function and fertility. Women have their uterus and ovaries. It is noteworthy.”
Dr. Cercek and Diaz want people with rectal cancer tumors, MMRd, to know that clinical trials continue to enroll patients and grow. Dr. Diaz said: “Our message is to test for rectal cancer to see if the tumor is MMRd. It is being tested at MSK regardless of the stage of the cancer. MSK has special expertise. It’s really important. “
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