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Women are still underestimated in many clinical trials-Consumer Health News

Women are still underestimated in many clinical trials-Consumer Health News

 


Thursday, June 23, 2022 (HealthDay News)-Patients of all types need to participate in clinical trials to ensure safe and effective medicines and devices, but new research shows Expression of women We are lagging behind in major disease areas.

Researchers at Brigham and Women’s Hospital (BWH) in Boston surveyed women’s participation in adult cardiovascular, psychiatric, and cancer clinical trials, and the percentage of women enrolled was the percentage of women affected by the disease. I found that it did not reflect.

“Although there is an overall improvement in women’s participation in clinical trials, it is still underestimated in studies to which women are legitimately affiliated,” said study co-author Connors Women’s Health Gender Organism. Dr. Primavera Spagnolo of the Academic Center said. BWH psychiatry.

“To ensure that the results of clinical studies benefit all affected individuals, the clinical trial population should be more closely aligned with the population statistics of the affected population,” Spagnolo said. Said in a hospital news release.

For research, the research team analyzed data from ClinicalTrials.gov, A database of 4-year private and public clinical studies from 2016 to 2019. Investigators assessed the average number of women enrolled for a particular disease area and study.

In 1,433 trials involving more than 302,000 people, researchers found that about 41% of the participants were women.

Upon closer analysis, the researchers found that 49% of the cardiovascular disease patient population was female, compared to just under 42% of the study participants. Similarly, 51% of cancer patients are women, but only 41% of clinical trial participants are women.

The gap was particularly large in psychiatric clinical trials, with approximately 42% of study participants being women and 60% of psychiatric patients being women.

“In designing this study, we decided to assess cardiovascular disease, cancer, and psychiatric disorders, as the first two are the leading causes of death in women and the latter are the leading disorders of women worldwide. We did, “said Spagnolo. “We found that women are still underestimated in clinical trials, which represents an important barrier to clarifying the difference between men and women. [the] The safety and efficacy of drugs and devices. “

The findings were published in a recent special issue Modern clinical trialsDedicated to the health of women.

“The increase in female participation in clinical trials is certainly promising, but our work is not perfect. We simply can’t rest,” said Spagnolo. “We need to continue to monitor female representatives in disease-specific clinical trials to ensure that patients are properly cared for and that drugs and devices are truly safe and effective. Importantly, interventions. And develop an approach to include diverse groups of women in clinical studies. “

For more information

In the office on women’s health, Health problems affecting women..

Source: Brigham and Women’s Hospital, News Release, June 21, 2022

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