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ICMR begins research to assess BCG booster doses in children and adolescents

ICMR begins research to assess BCG booster doses in children and adolescents

 


CHENNAI: Scientists at ICMR’s National Institute for Research in Tuberculosis in Chennai plan to initiate a study on BCG booster dose for kids and adolescents, who are household contacts of tuberculosis patients. The purpose is to understand whether to prevent. As a result, more than 9,000 children are registered on seven sites in India.

The primary aim of this study is to assess the efficacy of BCG re-vaccination compared to oral chemoprophylaxis in preventing tuberculosis (TB) in household contacts aged 6-18 years. Chemical prevention.

The Bacille Calmette Guerin (BCG) vaccine is one of the most widely used vaccines in the world to reduce the risk of natural tuberculosis infection. The efficacy of BCG vaccination in newborns is well known and has been demonstrated to be protective against meningitis and disseminated tuberculosis in children.

However, there is considerable uncertainty about re-vaccination with BCG. Although BCG re-vaccination is known to enhance the immune response, it has not yet been established whether BCG re-vaccination helps prevent tuberculosis in home contact.

“The study is designed as a multicenter randomized controlled trial with two groups of healthy household contacts aged 6-18 years receiving either the BCG vaccine or oral chemoprophylaxis. Followed for 24 months to compare the incidence of tuberculosis in each group. This study will demonstrate the effect of BCG re-vaccination on the incidence of tuberculosis in healthy household contacts aged 6-18 years compared to oral chemoprophylaxis, “said NIRT Director C Padma. Dr. Priya Darsini told Mint.

“ICMR has had one consultation with the Ministry of Health and another meeting is scheduled for next week. Currently, the number of children in this age group who have developed tuberculosis and who died from the disease. There are no reported data on the number of children, “said Dr. C Padmapria Darsini.

“All children will be home contacts of microbiologically confirmed patients with pulmonary tuberculosis. Adult contacts with multidrug-resistant (MDR) TB will also be included in the study. C-Tb skin test positive and Both negative children are included. Similarly, both malnourished and malnourished children are included. All children are followed for 24 months after recruitment and the incidence of tuberculosis (all forms). Is compared between groups. Tuberculosis is diagnosed according to the National Tuberculosis Eradication Program (NTEP), and latent tuberculosis infections (LTBI) are based on the results of C-TB skin tests.

Scientists are waiting for the release of funding and are aiming to start their research as soon as possible. They aim to complete the study by 2025 to meet the Ministry of Health’s deadline for the TB eradication goal by 2025.

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