Health
Genetic heart disease can only be cured in the “decisive moment” | Heart disease
Scientists are set to develop the world’s first cure for genetic heart disease by rewriting DNA in a move that is welcomed as the “decisive moment” in cardiovascular medicine.
A global team of experts from the United Kingdom, the United States and Singapore are working together to design an arm jab for patients to save the lives of thousands after receiving a £ 30 million grant from the British Heart Foundation. increase.
The team will design and test the first treatment for hereditary cardiomyopathy using a precision gene technique called base and prime editing for the first time in the heart with the goal of silencing defective genes. Animal testing has already shown that the technique works.
“This is a crucial moment in cardiovascular medicine,” said Professor Sir Nilesh Samani, medical director at BHF.
Hereditary myocardial conditions are caused by a variety of abnormalities in the heart that can cause sudden death and progressive heart failure. About 260,000 people in the UK are in this state and can die suddenly at any age.
Every week in the UK, 12 people under the age of 35 die of undiagnosed heart disease. This is often due to hereditary cardiomyopathy, also known as hereditary cardiomyopathy.
Everyone with hereditary cardiomyopathy has a 50/50 risk of inheriting the defective gene in each child, and often several members of the same family develop heart failure or require a heart transplant. , Die at a young age.
The team behind the new study was selected by an advisory board chaired by Professor Sir Patrick Valence, Principal Scientific Advisor to the UK Government.
Professor Hugh Watkins of Oxford University CureHeart projectSaid that cardiomyopathy is “really common” and affects 1 in 250 people worldwide.
“This is a once-in-a-generation opportunity to free our families from sudden death, heart failure, and the constant worry of the potential need for a heart transplant,” he said. “Thirty years of research have uncovered many genes that cause a variety of cardiomyopathy, specific genetic defects, and how they work. Over the next five years, clinical trials of gene therapy I believe I’m ready to start with. “
Under the new research program, experts hope to permanently correct or silence the mutated genes involved in causing these heart problems.
Sign up for our free daily newsletter, First Edition – 7am BST on weekdays
Christine Seedman, a professor of medicine at Harvard Medical School in the United States and co-leader of the CureHeart project, said the idea was to “fix the mind” and bring it back to normal functioning.
“Most of the mutations we see in human patients have a huge number of mutations, [mutations] – They all change one letter of the DNA code frequently, “she said. “This made it more likely that we could change that one letter to restore the code and create a normal gene with normal functioning.”
She said some “very elegant chemistry” has already advanced the field of science, adding:
“We may be able to offer these treatments prior to the disease. Individuals known by genetic testing are at an extraordinary risk of developing the disease and progressing to heart failure. It has never been possible to provide and that is the purpose of our project. We know it can be done and aim to get started. “
|
Sources 2/ https://www.theguardian.com/society/2022/jul/29/genetic-heart-conditions-could-be-cured-first-time-defining-moment The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
