Health
Can memory loss be reversed?Study Discovers Mechanism That May Combat Age-Related Symptoms
It’s well known that aging appears to affect memory and social interactions, but little is known about why this happens and future treatments to prevent it. have long wondered why this dysfunction occurs, but new research has revealed some important new information.
With the help of aged mice, researchers have identified a novel mechanism in neurons that causes memory associated with these social interactions to decline with age, and were able to reverse this memory loss in the laboratory. rice field.
What our research found about memory issues:
It is important to note that currently there are no drugs that can prevent or reverse cognitive decline due to typical causes. agingAccording to a new study, researchers report their findings identified specific targets in the brain. It is different from what can be
Michy Kelly, PhD, Associate Professor of Anatomy and Neurobiology at UMSOM, who led the study, said: Which face was your name on? ”
Researchers can study the ‘social interaction’ of mice with their neighbors by examining whether they are willing to try a new food based on their memory of encountering that food in another mouse’s breath. .can get sick or even die from it, according to Year report. When a mouse smells food in the breath of another mouse, the mouse associates the food odor with the pheromone odor of the other mouse. This memory serves as a safety signal that the food with that smell is safe to eat in the future. the report said.
Dr. Kelly and her colleagues found that older mice can recognize both food odors and social odors separately, but are unable to remember the relationship between the two, similar to cognitive decline in the elderly. discovered. They also found that levels of PDE11A increased with age in both humans and mice, particularly in a brain region involved in many types of learning and memory known as the hippocampus. PDE11A was not found just in its normal location in young mice. Instead, it preferentially accumulated as small filaments in neuronal compartments.
Dean Mark T. Gladwin, MD, executive vice president of medicine at UM Baltimore and John Z. and Akiko K. Bowers Distinguished Professor at UMSOM, said: As the brain ages, basic research like this is essential to better understand it and ultimately find ways to prevent cognitive decline. ”
(with input from ANI)
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