Research to effectively model rotational traumatic brain injury and discover potential neuroprotective therapies

Dr. James A. Bibb’s lab has published its findings in the journal Scientific Reports.

Each year, millions of people worldwide suffer traumatic brain injuries (TBI). Caused by external forces such as a blow to the head that disrupt normal brain function, TBI can often result in a range of symptoms after the injury. Many patients report headaches, memory loss, poor concentration and attention, mood changes, and even sleep disturbances.

“These symptoms can be incredibly disruptive to a person’s daily life and can lead to poor quality of life, job difficulties, and strained relationships with loved ones.” Dr. James A. BibbChair of the University of Arizona School of Medicine-Phoenix Translational Neuroscience Division.

Despite the prevalence of TBI, available treatment options are limited. And most treatments now focus on managing symptoms rather than addressing the underlying damage. We attribute this to a lack of understanding of how it affects us.

Most TBI are the result of a fall, car accident, or sports-related head injury, in which the brain is damaged by rapid acceleration/deceleration of the brain within the skull. It’s very difficult to reproduce. “Few preclinical models of TBI replicate these negative rotational injuries, which makes it difficult to study the effects of TBI and test potential therapeutics in a controlled environment.” ‘he says Dr. Bibb.

However, a recent study by Umfress et al. al — was announced in scientific report Conducted in Dr. Bibb’s lab — highlighting the development of a new model of TBI induced by rotational acceleration.

Using complex mechanical engineering and high-speed telemetry, Dr. Bibb and his colleagues were able to design and characterize this new model. This has revealed many neuropathological consequences of injury.

Researchers used translational in vivo imaging of resident immune cells to demonstrate diffuse neuroinflammation after rotational head injury. Also, in partnership with Cell Signaling Technology, we utilized proteomic strategies to identify cyclin-dependent kinase 5 (Cdk5) as the primary culprit in his TBI-induced memory impairment.

They combined this with a novel inhibitor of Cdk5 (also discovered in Dr. Bibb’s lab) to demonstrate neuroprotection against these memory deficits and other neuropathological changes. Their progress provides fundamental steps towards modeling clinically relevant forms of TBI, identifying biochemical changes in the brain, and developing new neuroprotective therapeutics.

“The chronic effects of TBI include an increased risk of developing neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. It can lead to degenerative disease, which is a common condition in professional football players and other contact sports athletes,” explained Dr. Bibb. It is important for researchers to develop more effective treatments.

This multicenter study includes the Eric Jonson School of Engineering and Computer Science at the University of Texas at Dallas, the University of Texas Southwestern, the University of Alabama at Birmingham, Cell Signaling Technology, and the UArisona College of Medicine – Phoenix Department of Translational Neuroscience.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos