Would you like to downgrade the Covid-19 threat to a common cold threat?

Can Famous Cholesterol Lowering Drugs Help Treat Covid-19? Research team led by Hebrew University in Jerusalem Professor Yaakov Nahimias Early research says it looks promising.

Over the past three months, Dr. Nahimias and Benjamin Tenver at the Mount Sinai Medical Center in New York have been working on ways to alter a patient’s lungs to reproduce SARS-CoV-2, the coronavirus that is causing the current pandemic. The focus has been on itself.

Their main finding is that the virus prevents the normal burning of carbohydrates. As a result, large amounts of fat accumulate in the lung cells, allowing the virus to grow.

This new understanding of SARS CoV-2 helps explain why patients with high blood sugar and cholesterol levels are at particularly high risk of developing Covid-19.

Laboratory of Professor Yaakov Nahmias of Hebrew University. Photo by Daniel Hannock

With this information in hand, Nahmias and tenOever have begun screening for FDA-approved drugs that interfere with the ability of the virus to replicate. In a laboratory study, the cholesterol-lowering drug fenofibrate (Tricor) has shown very promising results.

By allowing lung cells to burn more fat, fenofibrate disrupted the viral grip on these cells. Within 5 days of treatment, the virus almost completely disappeared, the researchers said To report Sneak peak of Cell Press this week.

“These waves couldn’t come at a better time now, as the second wave of infections is soaring in countries around the world,” Nahmias said. “If our findings were corroborated by clinical studies, this array of treatments could not reduce the severity of Covid-19 to as severe as a common cold.”

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