Health
Coronavirus: Distinct Immune System Patterns in Severe Covid-19 Patients-Health
Researchers studying 125 immune reactions in hospital COVID-19 (new coronavirus infectious disease) (# If there is no character limit, add parentheses when first appearing Patients identified a clear immune profile or “immune type” and showed how they were related disease Advances that may help develop new treatments for severity and disease.
A study published in the journal Science remains unclear whether severe COVID-19 patients have a common profile of immune dysfunction. Scientists, including Divij Mathew from the University of Pennsylvania in the US, “putting a patient on an immunotopology map can begin to infer what type of therapeutic intervention is most useful for a particular patient.” Said. To date, researchers have said that studies investigating this have been limited, reporting single patients or small cohorts.
They say that scientists around the world continue to investigate the characteristics of the human immune response in combating the global COVID-19 pandemic. In an effort to extend the findings reported to date and better link the immune function of COVID-19 patients to the clinical features of the disease, Mathew and colleagues collaborated on the first two points of 125 people. The cells of the immune system of COVID-19 patients were evaluated during the week of admission.
The researchers said they used a method called flow cytometry, a technique used to detect and measure the physical and chemical characteristics of cell populations and evaluate the immune cells of patients. They also said the study also collected clinical data on a patient cohort.
Combining clinical data with flow cytometry, the study reported several important findings, including a hallmark of COVID-19 disease in this group being variability in its immune response. He also noted that the signature of constant, stable immune responses in a subset of patients changed in a consistent manner over time.
Some of these patterns, like defective activation of the immune system called CD8 T cells, were associated with worse disease outcomes, according to the researchers. Scientists have defined three of these immune response signatures, or immunotypes, associated with patients with poor clinical trajectory compared to improved health.
“These immunotypes may reflect fundamental differences in how patients respond to SARS-CoV2 infections,” they said. Scientists believe the finding “inspires the idea of tailored clinical treatment or future immune-based clinical trials where the immunotype suggests greater potential benefit.”
(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)
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