Health
Semaglutides Wegovy and Ozempic improve blood sugar and reduce weight long-term
Semaglutides—weight loss and diabetes injectables like Wegovy, Ozempic, and Rybelsus—significantly improved blood sugar control and weight in adults with type 2 diabetes over a three-year period, according to new data released Monday at a major endocrine conference.
Results of the study—funded by Ozempic manufacturer Novo Nordisk—were presented by the Israeli researchers at the annual meeting of the European Association for the Study of Diabetes in Hamburg, Germany.
Scientists retrospectively analyzed the data of more than 23,000 diabetic patients who used semaglutide. Six months after starting treatment, patients’ HbA1c levels—from a blood test that measures a person’s average glucose level over the previous 8-12 weeks—improved, falling an average of 0.77%. Body weight dropped by an average of 10 pounds.
Results were maintained over three years, among patients who took the drug that long, according to researchers, with weight down around 13 pounds throughout. HbA1c results remained down an average of 0.76% at the two-year mark and 0.43% at the three-year mark. A one-percentage-point reduction in HbA1c typically equates to a 40% reduction in the risk of diabetic complications like vision loss, heart disease, stroke, kidney failure, amputation, and premature death.
The study represents the first long-term, large-scale, real-world trial of the blockbuster drug, researchers say. And its findings support the weekly use of the drug by type 2 diabetics, lead researcher Dr. Avraham Karasik, of the Maccabi Institute for Research and Innovation at Tel Aviv University in Israel, said in a news release about the study.
Results align with those of clinical trials of the drug, Karasik added—and they come as no surprise, according to experts Fortune spoke with.
While the findings were as expected, “large-scale, observational data to back up data from randomized clinical trials are helpful,” Dr. Utpal Pajvani, associate professor of medicine in the division of endocrinology at Columbia University in New York City, New York, tells Fortune.
Dr. Deborah B. Horn, an obesity medicine expert at UTHealth Houston in Texas, tells Fortune that “it is always reassuring to see results from a controlled environment like a clinical trial reproduced in the real world,” and added that the HbA1c and weight changes mirror what she sees in patients.
The take-home messages from the study, according to Horn: “If you take your medication consistently, you do better.”
A ‘wonder drug’ with both risks and benefits
Semaglutides, injected weekly, mimic a hormone produced in the intestines after meals called glucagon-like peptide-1 (GLP-1). It helps regulate appetite and food intake.
The U.S. Food and Drug Administration approved one of Novo Nordisk’s formulations, Wegovy, in 2021 for weight management in adults with obesity, type 2 diabetes, and/or high cholesterol. It’s intended to be used in conjunction with dieting and exercise. The FDA approved another Novo Nordisk formulation, Ozempic, as a treatment for Type 2 diabetes in 2017. And it approved the first oral semaglutide, Rybelsus, in 2019—also a Novo Nordisk product.
While semaglutides have been used to treat type 2 diabetics for six years and those with obesity for two, recent research has revealed that the so-called “wonder drug” may also help combat other diseases, like heart disease and heart failure.
But it’s not without risks. So far, the drug has generally only been studied in patients for a one-year period. But beyond that time, the risk of intestinal obstruction—a potentially fatal condition that requires surgery—continues to increase in type 2 diabetics, peaking around a year and a half, researchers from China wrote in a letter to the editor published this spring in medical journal Acta Pharmaceutical Sinica B.
The U.S. Food and Drug Administration late last month updated its warning label for Ozempic, saying that the drug may lead to ileus, a condition in which the intestines don’t work correctly. Wegovy’s packaging information also acknowledges the risk.
|
Sources 2/ https://fortune.com/well/2023/10/02/wegovy-ozempic-semaglutides-improve-blood-sugar-weight-long-term-study/ The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
