Researchers cast doubt on efficacy of new Alzheimer's treatment – ​​POLITICO

Eli Lilly and Biogen did not immediately respond to requests for comment.

These drugs have also divided opinion among regulators.

U.S. Food and Drug Administration approved Last year, with lecanemab Donate a Mob This year. But last month, the European Medicines Agency Opposed The company filed suit to strip the license for lecanemab, known as Leqembi, arguing that the drug's slight benefit in slowing cognitive decline did not outweigh the risk of serious side effects.

The UK's medicines regulator, the Medicines and Healthcare products Regulatory Agency (MHRA), is still evaluating lecanemab and a decision is expected shortly.

“If these drugs are approved by UK and European regulators and become available, it is understandable that some people with early-stage Alzheimer's disease may still want to try these drugs, given the despair of living with this terrible disease,” said co-author Ed Richard, professor of neurology at Radboud University Medical Center in Nijmegen, Netherlands. “However, there has been a lot of exaggeration in the reports about these drugs, and it will take a lot of effort to provide balanced information to help patients make informed decisions,” Richard said.

“Few researchers thought that recent amyloid-targeting drugs would be the ultimate solution for Alzheimer's disease,” said Mark Dallas, associate professor of cellular neuroscience at the University of Reading in the UK. The Cambridge study highlights the limitations of these treatments and underlines the “urgent need for alternative strategies to improve the lives of people with dementia”, he added.

But others stress that these drugs still play an important role in the fight to find a cure for Alzheimer's.

“It remains to be seen whether the divergence of treatment and placebo curves will continue with longer-term treatment, but we now have disease-modifying therapies and it would be a shame if Britons who could benefit from them had to fly to the US,” said group leader John Hardy, professor of neuroscience at the UK Dementia Institute, University College London (UCL).

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