College football picks, schedule: predictions against the spread, odds for NCAA top 25 games in Week 6

October is here, and that means conference play is on the rise halfway across the country college football The regular season is getting closer. Saturday's Week 6 slate is packed with subsequent league battles.

Nine of the top 10 teams in the AP Top 25 are in action this week, with all nine playing conference play. But of that group, only No. 9 Missouri will face another ranked team as the Tigers play their first road game of the season when they travel to Kyle Field to take on No. 25 Texas A&M at noon ET.

While the league action continues to heat up, there is a particularly meaningful non-conference game worth keeping an eye on in the afternoon as Air Force hosts Navy. The Midshipmen are off to a 4-0 start and are looking to win the Commander-in-Chief's Trophy for the first time since 2019. While Air Force is just 1-3, the Falcons will be motivated to defend their home court and are off to a 1-0 start in the annual round-robin between the service academies.

Be sure to stick with CBS Sports all day Saturday for college football coverage from the opening kickoff. Let's take a look at our expert picks for the best games in Week 6.

Odds via SportsLine Consensus| Always Oriental

Navy in the Air Force

Afternoon|CBS,Paramount+ with ShowtimeCBSSports.com,CBS Sports App—While history is certainly not on Navy's side, this is a game – on paper at least – that the Midshipmen should win easily. Air Force has lost each of its three games against FBS opponents by at least two possessions. The Falcons weren't particularly good on either side of the ball. They scored in double figures for the second time this season by putting 19 points on the board against Wyoming in Week 5…and still lost 31-19. Two Air Force opponents have surpassed the 30-point mark this year, and now they'll face a Navy team that leads the AAC in scoring (46 points per game). Choice: Navy -9.5 (-113) –Will Backus

No. 9 Missouri at No. 25 Texas A&M

Afternoon |ABC,fubo(Try for free) —Missouri had the talent edge in every game as it started 4-0 with a series of home games highlighted by close wins against Boston College and Vanderbilt. Now the Tigers head to one of the toughest environments in the country to take on a Texas A&M team that has just as much, if not more, talent on the roster. Mizzou struggled to slow down Vanderbilt quarterback Diego Pavia and now faces a similar challenge with A&M's mobile Marcel Reed. The Aggies have been tested and will bring enough physicality and enthusiasm on the home court to keep Mizzou off balance. Pick: Texas A&M -2.5–David Cobb

3.30 pm |CBS,Paramount+ with ShowtimeCBSSports.com,CBS Sports App—Ohio State has barely opened the playbook against a Charmin-soft early schedule, but the Buckeyes are well prepared for their close match. Iowa has the ability to blow the game away, but even an improved Hawkeyes offense won't be able to seriously keep pace with an OSU defense that is among the best in the country. It may be a backdoor cover, but Ohio State will get there.Pick: Ohio State -19.5 — Shehan Jeyarajah

3:30 PM | ABC,fubo(Try for free) —Auburn is coming off back-to-back home losses to mid-tier SEC teams and now has to go on the road with a 2-3 record to play an angry Georgia squad. The Bulldogs came back from a 30-7 deficit at Alabama last week, only to lose in heartbreaking fashion. It is only the second time this season that the country is at home and has to face a historic rival. So the idea is for Georgia to open up with the same intensity as they did in the second half against the Crimson Tide and cover this significant spread.Pick: Georgia -24.5 — Cobb

7:30 PM | ABC,fubo(Try for free) —Tennessee held back against Oklahoma, choosing to lean on the running attack instead of continuing it after building a 22-3 lead two weeks ago. However, Arkansas presents a different challenge, especially with a mobile quarterback. This should be a solid test for Tennessee's elite and deep defensive line, especially against the run. The Razorbacks have struggled as a pass pro, but they are solid with the run, ranking 21st nationally with 212 yards per game. Ja'Quinden Jackson is averaging 6.4 yards per carry and quarterback Taylen Green is the second-leading rusher with 66.2 yards per game. The Hogs are trying, thoughtoo difficultto make plays when things break down and it leads to costly turnovers, leading to losses for Oklahoma State and Texas A&M in one-possession games. Arkansas ranks among the worst in the SEC in turnover margin (14th), and Tennessee's defense is among the best in the nation in every category.Pick: Arkansas +13.5 –Brandon Marcello

SportsLine's proven computer model calls for seven unmitigated upsets in Week 6 of college football.Visit SportsLine now to see them allplus staggered choices for each game from the model that simulates each game 10,000 times.