Health
RSV vaccine is highly effective in adults over 60 years old
JAMA network open published a new study demonstrating that the respiratory syncytial virus (RSV) vaccine is 90% effective in reducing both RSV-related hospitalizations and emergency department (ED) visits in adults 60 years and older.
the study The 2023-2024 RSV season and outcomes seen in adults 60 years and older who were hospitalized or visited the emergency department at Kaiser Permanente in Southern California from November 24, 2023 to April 9, 2024 Provides real-world VE data based on
All participants had respiratory swabs taken and tested for RSV. Although previous trials have shown high VE, most of the adults tested were over 75 years old. Vaccination during the first RSV season after licensure of the RSVpreF (Abrysvo) vaccine and at least 21 days before onset of illness was the primary assessment.
Abrisvo approved It is expected to be used in the United States in June 2023 as a single-dose vaccine aimed at protecting older adults from severe respiratory syncytial virus infections.
A total of 7,047 lower respiratory tract hospitalizations or ED encounters due to RSV test results were included in the study. The mean age of patients was 76.8 years, 54.2% were female, 33.0% were Hispanic, and 36.9% were non-Hispanic white.
90% VE of the first season
14% of patients were immunocompromised. Overall, 8.8% (623/7,047) had a positive RSV test and 3.2% (223/7,047) received RSVpreF. Of the 6,424 tested negative controls, 221 (3.4%) were vaccinated.
If RSVpreF was received an average of 58 days before onset of symptoms, the adjusted VE was 90% (95% confidence interval) when the authors used extensive controls. [CI]59% to 97%). Using strict controls, the rate was 91% (95% CI, 59% to 98%). Efficacy was maintained through 5-month follow-up.
Approximately for every 250 people vaccinated, one incident of RSV-related ED or hospitalization can be prevented in the first season after vaccination.
“Based on our study results and the incidence of RSV in older adults, approximately one RSV-related ED or hospitalization could be prevented in the first season after vaccination for every 250 people vaccinated. “, the authors write. “These data suggest the use of RSVpreF in older adults and provide an opportunity to reduce the burden of severe RSV disease requiring medical care.”
RSV poses a significant disease burden to adults in the United States. Each year, approximately 160,000 RSV-related acute respiratory infection hospitalizations and 120,000 emergency department visits are associated with this virus.
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Sources 2/ https://www.cidrap.umn.edu/respiratory-syncytial-virus-rsv/rsv-vaccine-shows-high-efficacy-adults-60 The mention sources can contact us to remove/changing this article |
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