Health
NUS researchers develop microneedle technology to accelerate diabetic wound healing
Iso-based extraction microneedles for removing proinflammatory compounds
While the majority of microneedle techniques use materials for delivery, the NUS team investigated the new use of microneedles to extract unwanted proinflammatory proteins and immune cells in a second approach. To do this, the NUS team had to find the right coating material that could serve as a sponge to absorb proinflammatory compounds known as chemokines, which are “messenger” molecules that recruit and capture proinflammatory immune cells called monocytes in wounded tissue.
The researchers screened a variety of materials and ultimately used heparin-coated porous microneedles (HPMNs) to address the issue of persistent inflammation in the skin wounds of the source. Based on previous studies, heparin has been found to easily bind to chemokines. The team demonstrated that HPMN can effectively deplete chemokines and monocytes from the wound site, resulting in a 50% reduction in tissue inflammation and a 90% reduction in 14 wound sizes.th Treatment day.
These initial findings highlight the potential of HPMN as a promising strategy for the treatment of inflammatory skin disorders. The ability of HPMN to remove chemokines and inflammatory cells deep within skin tissue offers unique advantages over existing therapies that target only surface level inflammation. HPMN can be further developed for gendered wound care and for tailored treatment of a variety of inflammatory skin conditions, such as psoriasis.
Next Steps
The development of SUC-MN and HPMN represents a major advance in the field of wound healing and skin disease management. The team intends to conduct further research to investigate the potential of this technology and bring it to the market.
Especially for extractive microneedles, the team uses advanced techniques such as 3D printing to manufacture microneedles with more controllable pore sizes, and integrates antibacterial properties with clinically non-healing wounds into the microneedles. We also designed flexible microneedle patches to ensure they are suitable for a variety of tissue shapes.
“We are excited by the potential impact of our research and look forward to moving this technology towards clinical translation. The two approaches developed by our team provide much needed relief for patients with diabetic wounds and many patients suffering from skin conditions such as atopic dermatitis and psoriasis.”
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Sources 2/ https://news.nus.edu.sg/microneedle-technology-accelerate-diabetic-wound-healing/ The mention sources can contact us to remove/changing this article |
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