Health
The virus uses “decoys” to hide from the immune system and discover new research
New Zealand scientists have further discovered how the virus works and can evade the immune system.
According to research, published in journal mBio, The research team is currently using the findings to learn more about Covid-19. Recent studies have particularly focused on the Oryctes rhinoceros nudivirus (OrNV) virus, an important biocontrol agent against the coconut beetle, a devastating coconut and oil palm tree pest in Southeast Asia and the Pacific Islands.
The researchers found that the virus used a “bait” strategy to evade the immune system, explaining that these findings are a small step toward a better understanding of infections.
“We continue to work in this area using the same method to investigate changes in cells infected with SARS-CoV-2,” said research author Dr. Mihnea Bostina of the University of Otago.
Using electron microscopy, the research team investigated the cellular changes that occur during Nudivirus infection and discovered a unique mechanism for how the virus works. This study revealed that the virus acquired a membrane in the nucleus of infected cells and was equipped to infect new cells at this precise location.
In contrast to other enveloped viruses (which are also enveloped viruses, such as coronaviruses), they derive membranes from other cell compartments, according to the researchers.
“Once fully assembled, the virus uses clever tactics to traverse different environments and is packed into different membrane structures until it is released at the cell membrane,” Bostina said.
Researcher Sai Bellamoor said that this strategy means that much of the virus released from infected cells is trapped in the cell membrane while traveling inside the infected organism.
“This means they are missed by the immune system, and you can use this membrane decoy to invade other types of cells without the need for virus-specific receptors,” she said. It was
“This shows for the first time a clever strategy available for insect viruses. It would be interesting to find the ability of other types of viruses, such as those that infect humans, to perform similar processes,” Velamoor adds. It was.
This study shows another way in which a virus can take over infected cells and warns scientists about a new mechanism of viral infection.
“The virus will never continue to amaze us with their insatiable weapons of tricks. Only by studying them can we be prepared to respond appropriately when they infect us.” The study authors wrote.
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