Health
Immune cells in the brain that promise cell targets for therapy
WASHINGTON, September 08, 2020-Inspired by the need for new and better treatments for neurodegenerative diseases such as Parkinson’s and Alzheimer’s, researchers at Rutgers University show uncontrolled inflammation in the brain Is investigating the link between immune cells in the brain and microglia.
Most treatments for brain health disorders focus on neurons, the major cells of the nervous system. However, microglial cells have emerged as promising cell targets because they play a prominent role in brain inflammation. In addition, microglial behavior can be designed to suppress inflammation and the damage it causes by various factors.
To APL bioengineering, AIP Publishing Group highlights design considerations and benefits in creating therapeutic nanoparticles for the delivery of pharmacological agents directly to the sites of microglia.
Microglia are essentially the first responders to pathological changes in the brain and can easily remove unwanted or foreign material.
“Emerging drugs and biological agents could be targeted and released in a controlled way in the brain if they could manipulate nanoscale carriers,” said Prabus V. Mogé, co-author of the paper. There is.” “We believe that this area is ripe for technological, biological, and clinical breakthroughs.”
The group’s ultimate goal is to reduce the uncontrolled activation of microglial inflammation.
“We are developing a new therapeutic strategy within the Rutgers laboratory targeting microglia that are activated by excessive deposition of the protein alpha-synuclein,” Moge said. “This potentially addresses a major therapeutic barrier to microglial activation in neurodegenerative diseases.”
Targeting microglia in this way may pave the way for the development of new therapies.
“Study of the interaction of microglia and nanoparticles can lead to the design of successful nanomedical platforms that enable targeted delivery of drugs with minimal off-target effects and system-level toxicity. It can be done,” Moge said. “It may be worth directing treatment to the mediator microglia, given the complex nature of neurodegenerative disorders, rather than just focusing on neuron treatment.
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