Health
Blood cell test to identify high risk of COVID-19 in patients: study
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(IANS)
The researchers say that standard tests that evaluate blood cells are at high risk of becoming critical and potentially dead among patients hospitalized with COVID-19.
“We wanted to find a way to identify high-risk COVID-19 patients as quickly and easily as possible-which inpatients are likely to become severely ill and which are likely to get worse soon,” the research study said. Said John M. Higgins. Massachusetts General Hospital in the United States.
Higgins points out that early reports from China show that the body’s inflammatory response is very strong in some patients and very mild in others.
Previous studies by his own group have shown that specific changes in the number and type of blood cells during inflammation are associated with poor health outcomes in patients with diseases such as heart disease, cancer, and diabetes. did.
“We have restructured our computing infrastructure to analyze the rapidly growing COVID-19 patient cohort in the Boston region last year,” said Brody Foy, a research author at Harvard Medical School. ..
Their analysis, published in the journal JAMA Network Open, showed that all patients diagnosed with SARS-CoV-2 infection and admitted to one of four hospitals in the Boston area from March 4 to 28, 2020. Adults were included.
Before looking for complex changes in the circulating blood cells of the 1,641 patients included in the study, scientists first searched for patterns using routinely available blood tests.
“I was surprised to find that one standard test to quantify changes in red blood cell size (called the red blood cell distribution width, or RDW) is highly correlated with patient mortality,” the researchers write. It was.
The correlation persisted when controlling patient age, some other laboratory tests, and other identified risk factors such as some existing illnesses, “they added.
Patients with RDW values above the normal range on admission had a 2.7-fold increased risk of death, with a mortality rate of 31% and 11% for patients with normal RDW values.
In addition, increased RDW after hospitalization is associated with an even higher risk of death, indicating that RDW can be tracked during hospitalization to determine if a patient is responding to or worsening treatment.
Investigators are currently trying to elucidate the mechanism that causes elevated RDW in severe COVID-19 cases.
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