According to experts, cancer cured by canine cowpea mosaic virus has undoubtedly promising results in humans.

Cowpy mosaic virus (CPMV) is a typical member of the genus Comovirus. Researchers believe that the virus helps treat human cancer because it has found promising results by injecting the virus into tumors in dogs and mice.

Jack Hoops, a veterinary radiologist at Dartmouth College in New Hampshire, has spent decades of careers treating canine cancer with the latest therapies, but one day these are human I hope it will also help in the treatment of cancer. Recently, many of his patients have come to him with oral cancer, killing them within a few months if left untreated, and likely to recur even if the cancer is suppressed after radiation therapy. ..

These dogs are patients in an study conducted to investigate the effectiveness of new cancer treatments based on the popular plant virus cowpy mosaic virus. After treatment, several dogs were found to have completely eliminated their tumors and lived a long, cancer-free natural life.

Hoop believes that this treatment could be a breakthrough that can save the lives of millions of humans and dogs. “If the treatment works for canine cancer, it’s a human patient and it’s very likely that it will work at some level,” he said. Said..

Cowpea mosaic virus and cancer treatment

The virus does not replicate in mammals like plants, but researchers who developed this treatment can provoke an immune response that can play a major role in the treatment of several types of cancer. Said there is.

Immunotherapy has emerged as the most promising type Cancer treatment It involves developing the patient’s own immune system to recognize cancer cells (which the system does not always do) and fight back. That’s where the virus can help.

Hoop and his dog patient

Hoop injected 200 micrograms of non-living virus-like particles into a dog’s tumor. Each dog received four doses of virus particles over a two-week period while receiving standard radiation therapy.

CPMV has proven to be more effective than any other pathogen researchers are currently trying to boost immunity. However, it is not very clear why the virus is so uniquely effective. “It’s more effective than the radiation itself, which is a big plus for us. The immune system is stronger than we thought it would be,” said Hoops.

A similar process using a recombinant oncolytic virus was analyzed by researchers, but Steve Fearing, an immunologist at Dartmouth College, said, “Any of the oncolytic viruses have been very effective in clinical trials. Does not show. ” Currently, only three oncolytic virus therapies are approved. cancer Treatment around the world.like paper, A global clinical trial studying oncolytic viruses for their effectiveness in some cancer treatments “remains little known.”

However, the paper was published in 2015 Nature nanotechnologyResearchers have stated that cowpy mosaic virus not only creates immune memory in mice, but is also very effective in treating tumor models of melanoma, breast, ovary, and colon.

Researchers who developed a cure this summer and worked with Hoops to study dogs $ 2.9 million grant The National Institutes of Health (NIH) has developed a bioprint implant for the treatment of ovarian cancer with the virus.

Earlier this year, researchers co-founded the company —Mosaic IE— To facilitate human trials of virus-based therapies. But before that, they need to do extensive toxicological research to ensure their safety. “Everything needs to be very carefully documented and tested before starting a clinical trial,” Fireling said.

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