Health
Canadian Researchers Investigate Whether Tuberculosis Vaccines Provide COVID-19 Protection | Health
Researchers in Toronto-Canada have begun research to determine if a 100-year-old vaccine against tuberculosis can provide some protection against COVID-19.
Researchers at the University Health Network in Toronto want to test the theory that Bacille Calmette Guerin (BCG) can reduce the incidence and severity of COVID-19 infection.
The study targets police, firefighters, and healthcare professionals at high risk of COVID-19 exposure, and researchers want to recruit more than 3,600 participants.
Dr. Alexander Zlotta, principal collaborator, said that if cheap vaccines prove to be useful, they can be quickly deployed to provide temporary protection until COVID-specific vaccines are widely available. Stated.
According to the Toronto Public Health, BCG continues to be used in Europe and developing countries, but Canada ceased routine use in the early 1970s.
Although cases of tuberculosis in Canada are one of the lowest in the world, certain vulnerable populations are at increased risk of infectious bacterial disease.
A double-blind, placebo-controlled trial called “COBRA” is being developed in parallel with trials in Germany and the United States. Experts will announce the results in May 2021.
Interest in BCG emerged early in the pandemic when researchers realized that COVID-19 mortality was significantly lower, even in countries with high BCG coverage. However, recent analyzes that reflect pandemic movements around the world are contrary to that idea.
“Lack of Evidence of BCG Vaccine Protection from Severe COVID-19” states the headline of a letter published in the minutes of the National Academy of Sciences on September 29.
Citing the latest analysis based on data from the Johns Hopkins University Coronavirus Resource Center, the study found that Bolivia, Panama, Colombia, Peru, Brazil, Mexico and South Africa had the largest number of COVID-19 deaths on August 1. It states that it showed an increase. It also has high BCG coverage.
The letter concludes by stating that ongoing randomized controlled trials should provide a more specific answer.
According to UHN, Canadian studies are using improved versions of the vaccine, and researchers hope it “helps evoke a stronger immune response.”
“The big advantage here is that this vaccine has been given to billions of people around the world in the last few decades,” Zlotta said in a release.
“Safe and readily available. If the study is successful, this could be an important strategy for controlling pandemic secondary waves.”
This study is funded by the Princess Margaret Cancer Foundation.
This report by The Canadian Press was first published on October 6, 2020.
Canadian press. all rights reserved.
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