Chemical flaking may interfere with male sex hormone receptors

ENDO 2020, research accepted for presentation at the Annual Meeting of the Endocrine Society, and Journal of the Endocrine Society.

Research has found that chemicals can block the effects of testosterone and other male sex hormones known as androgens.

Phum Tachachartvanich, Ph.D., a principal investigator at the University of California, Davis at Ph.D. It is a prostate development disorder. “

Hydraulic fracturing technology has greatly improved the extraction yield of oil and natural gas from unconventional sources. Flacking is a mixture of industrial chemicals High pressure In a horizontal borewell. According to Tachachartvanich, breaking chemicals can pollute the environment, such as lakes, groundwater, and wastewater, and affect anyone exposed to this group of chemicals.

“The widespread use of fracking has raised concerns that it can adversely affect both the environment and human health,” said Tachachartvanich. “Everyone needs to worry about fracking because the generated wastewater has endocrine disrupting effects and can have a negative effect on the general population.”

Researchers Computer model Rank 60 Hydraulic fracturing Chemicals used in California based on the expected potential of each chemical to interfere with the ability of androgens to bind cells in the body. Based on the ranking, they used a cellular model to examine the top five flaking chemicals that were most likely to disrupt this process.

Next, the androgen binding activity of each cell model was measured. chemicals. Of the five HF chemicals tested, only one (Genapol-X100) significantly inhibited androgen binding activity. “This suggests that Genapol-X100 has endocrine disrupting potential,” Tachachartvanich said.

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Hormone-disrupting activity of flaking chemicals worse than first discovered

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Provided by

Endocrine Society

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