Health
Antibody therapy for playing cards not made from embryonic stem cells
Claim: The antibody cocktail playing cards received are made from fetal stem cells
Medical professionals since President Donald Trump’s COVID-19 diagnosis and hospitalization Expressing concern Regarding his wide range of medical regimens, including the steroid dexamethasone and Gilead’s remdesivir. In particular, one treatment, Regeneron Pharmaceuticals’ antibody drug, has been criticized on social media.
“Therefore, it turns out that the monoclonal antibody used by Trump is from fetal stem cells. Therefore, Trump is being treated / preserved in dead babies,” he reads on Twitter. Share on Facebook group Dogs for Democracy..
The tweet continues calling for Republican and Supreme Court candidates Judge Amy Coney Barrett, And anti-abortion activists.
Follow-up tweets with a link to Regeneron’s official view Studies on stem cell research are provided as evidence of the claim.
Facebook posts that share tweets haven’t received much attention on the platform, but have become a hot topic on Twitter, with over 347,000 likes and 107,000 retweets. Similar tweets It’s also viral, including those from Person Ted’s location, D-Calif.
USA TODAY has contacted the Dogs for Democracy Facebook Group admin for further comment.
Fact check:Trump hospital records, weight not released
What is Regeneron’s antibody cocktail?
When the human body is invaded by foreign pathogens (bacteria, viruses, fungi, parasites, etc.). Y-shaped protein called antibody Will be formed. They circulate in the body, sequestering other immunochemicals and cells, warning and destroying pathogens. It’s like a search and destruction system.
Antibodies are genetically engineered by the body to, in a sense, recognize specific pathogens, thus forming the basis of “adaptive” immunity. This genetic engineering occurs in white blood cells called B cells. B cells produce and display proteins on the cell surface by genes that have been rearranged like a series of numbers that have been rearranged to form different sequences or patterns.
Since this rearrangement is random, we do not know what specificity the antibody will show or whether it will be biologically useful. Only when B cells encounter the right pathogen at the right time will they activate and secrete their custom antibodies. Activated B cells clone themselves through a process called clonal proliferation. It helps initiate an effective immune response by producing large amounts of antibodies and memory B cells (B cells that remember future break-in encounters). Not only activates other immune cells.
Regeneron’s antibody “cocktail,” known as REGN-COV2, is a combination of two monoclonal antibodies, a monoclonal that refers to a particular B cell clone. These antibodies, REGN10933 and REGN10987, are designed to lock on to the SARS-CoV-2 spike protein and prevent interaction with the target ACE2 receptor on the host cell surface.
REGN-COV2 began its first clinical trial in June and is currently participating in four late-stage clinical trials, which are estimated to recruit a total of at least 11,000 participants. According to the news of genetic engineering and biotechnology..
Antibody therapy has so far shown to be able to reduce SARS-CoV-2 viral load and disease In an experiment with golden hamsters and rhesus monkeys.. Findings released last month from Regeneron’s preliminary experiments SARS-CoV-2 positive patients who are not hospitalized It also showed a decrease in viral load, from asymptomatic to moderate cases. However, more research is needed to find out how effective REGN-COV2 is.
Fact check:The satirical post falsely claims that it’s okay if Trump hasn’t been tested.
Misunderstood statement
Regeneron’s Alexandra Bowie on News Aggregation Platform Heavy October email The REGN-COV2 is not made from human embryonic stem cells.
“This particular discovery program (REGN-COV2) did not include human stem cells or ESC,” Bowie wrote.
The statement shared on Twitter is Regeneron’s official view of stem cell research in general and has nothing to do with how REGN-COV2 was made. Bowie also confirmed this heavy.
It’s unclear why Regeneron issued an official statement in April. Bowie did not clarify the timing in his email to USA TODAY, implying that it was a common practice among pharmaceutical companies and that Regeneron wanted transparency.
“Like many biopharmacy companies doing scientific research (see, for example, Pfizer, J & J), there is a general view on the use of stem cells,” Bowie said. “We share this and other similar statements for transparency and to help educate people about the steps we take to do business responsibly.”
The REGN-COV monoclonal antibody seems to be derived from a B cell line Separated from human donors Recovered from SARS-CoV-2 and immune mice designed to have the human immune system, USA TODAY focused on the fetal-derived cell lines mentioned in Regeneron’s earlier studies.
To Supplementary material To paper HEK293T cells, published in Science in June — Immortalized epithelial cell lines derived from fetal kidney cells (usually not immortal, but spontaneously mutated or immortalized in the laboratory) Obtained in 1972 — Described to be used “easily” to create viral particles such as SARS-CoV-2 to test antibodies of mouse and human origin.
Bowie asserted that HEK293T cells were used, but no repeated stem cells were used.
“This particular discovery program (REGN-COV2) did not include human stem cells or ESC,” she writes. “The 293T cell line was originally derived from human fetal kidney cells, but it is not a stem cell but an immortalized epithelial cell. These cells are transfected to produce” pseudoparticles “that mimic the spike protein of the virus. It was used. We test the neutralizing ability of our antibodies against viruses. “
Our rating: False
We rate this claim as FALSE as it is not supported in our research. The antibody therapy Trump received was not directly from fetal or embryonic stem cells, but from SARS-CoV-2 human survivors and immune mice engineered by the human immune system. Regeneron’s official statement, released in April, is cited on Twitter as the basis for its allegations, is a general position in stem cell research, and has nothing to do with how antibody therapy is actually performed. However, according to a supplementary material released in June, embryo-derived cell lines, although not stem cells, appear to be involved at least in the early stages of Regeneron’s testing process.
Fact check source:
- CNBC, October 5, “Doctors are concerned that Trump is a VIP and could be “overtreated” against the coronavirus.“”
- Congressman Ted Lieu, October 6 Twitter thread
- Guardian, October 1st “Apparently: Amy Coney Barrett supported a group that said life begins with fertilization“”
- LiveScience, July 17, “What is an antibody?“”
- British Society for Immunology, “Generation of B cell / antibody diversity.. “
- Genetic Engineering & Biotechnology News, October 5, “Trump’s Treatment: Regeneron’s Antibodies and Gilead’s Remdesivir Description“”
- Science, October 5, “Update: What is known about Trump’s COVID-19 treatment is:“”
- bioRxiv, August. 3, “The REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus monkeys and hamsters.“”
- Regeneron, September 29, “Regeneron’s REGN-COV2 antibody cocktail reduced viral levels and improved symptoms in unhospitalized COVID-19 patients“”
- Heavy, October 6th “Trump’s Regeneron monoclonal antibody treatment was not performed on human fetal stem cells“”
- Alexandra Bowie emails USA TODAY on October 7th
- Science, June 15, “Supplementary material for studies in humanized mice and convalescent humans produces SARS-CoV-2 antibody cocktails“”
- Science, June 5, “Abortion opponents protest the use of fetal cells with the COVID-19 vaccine.. “
- Johns Hopkins Medicine, “Henrietta Lacks Heritage“”
- USA TODAY, October 1st “Supreme Court candidate Amy Barrett has signed an anti-abortion letter accompanying an ad calling to overturn the Roe v. Wade case.”
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