Health
Blood tests can be developed to help predict pregnancy complications suggested by new studies
Researchers at UCLA say blood tests commonly used to detect genetic abnormalities in the fetus may help predict pregnancy-related complications before symptoms appear. Their preliminary study, EpigeneticsAssociates specific cell-free DNA signatures with adverse consequences during pregnancy such as ischemic placental disease and gestational diabetes.
The findings show that genetic material (circulating acellular nucleic acids) released from the placenta into the mother’s blood during the first trimester of pregnancy is potentially used to predict these potentially serious complications. It’s the first to show what you can do.
Analysis of genetic material in the mother’s blood has been used to screen for genetic abnormalities during pregnancy, but this is the first time these particular methods have been used as more accurate predictive methods. ..
“Our study shows a promising approach that can use existing techniques to improve the outcomes of mothers and their babies,” said UCLA Mattel Children’s Hospital, lead author and prominent pediatric professor. Dr. Sherinde Basker said. David Gefen School of Medicine. “If confirmed in a larger study, a cell-free DNA blood test may help identify placental problems as an indicator of healthy mothers and fetuses.”
Researchers tracked various groups of pregnant women from February 2017 to January 2019, blood Regularly during pregnancy. By the end of the study, 160 participants had given birth, with 102 maternal and 25 umbilical cord plasma samples taken along the way.They discovered it early on Late, Placenta-specific DNA increased among women who continued to develop gestational diabetes.They were also able to identify several differently expressed genes and create models with predictive hazards. pregnancy result.
“The novelty of this study is that it can break down the mother’s DNA and focus on placental health, something researchers couldn’t do before,” Devaskar added. “This study ensures that automated methodologies are applied to multicenter clinical trials to improve future testing and screening of all women.”
Giorgia Del Vecchio et al, Transcriptome Signature Prediction of Pregnancy with Cell-Free DNA Methylation and Adverse Outcomes, Epigenetics (2020). DOI: 10.1080 / 15592294.2020.1816774
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Quote: Blood tests suggest a new study (October 13, 2020) obtained on October 13, 2020 from https: //medicalxpress.com/news/2020-10-blood-pregnancy-complications.html May be developed to help predict pregnancy complications
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