Two Calpain Inhibitors and Inflammatory Bowel Disease Drugs May Treat COVID-19, Find Studies

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First case of COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears It was reported last December. In the next few months, scientists have suggested several drugs to treat the disease. Drugs such as remdesivir and favipiravir have been approved or licensed for emergency use while other drugs are still being studied.

Currently, in two different studies, scientists are proposing two new ways to combat SARS-CoV-2. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears ..

In a study conducted at the University of South Florida, researchers suggested drugs that could target both virus invasion and replication, and another group of researchers at Cedars Sinai said of inflammatory bowel disease (IBD). Describes anti-inflammatory drugs used for treatment) Can be used for treatment COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears ..

The study is published in the journal Science Advances And Gastroenterology,Respectively.

Kill two birds with stones

Scientists at the University of South Florida have sought compounds that can target two key steps in the life cycle of a virus: when they enter healthy cells and when they replicate within them.

Based on previous studies, they can target both of these processes by attacking the human host protein catepsin L, which is involved in viral invasion, and the SARS-CoV-2 protein Mpro, which is important for viral replication. I found some drugs.

Two compounds, called calpain inhibitors II and XII, especially the latter, have been found to be more effective against Mpro than another drug candidate called GC-376. GC-376 is a prodrug already used to treat deadly cats. Coronavirus Proposed as a potential remedy for illness and previously COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears .. Calpain is a proteolytic enzyme involved in various processes in the body.

X-ray crystallographic studies have shown that calpain inhibitors are perfectly compatible with the Mpro binding site. A binding site is a specific structural site of an enzyme to which a substrate (a compound on which the enzyme acts) binds. Interestingly, when the calpain inhibitor XII binds to that site, it changes its structure and fits snugly into the active site. Once the active site is taken, the enzyme will not function.

Because the drug acts on both Mpro and cathepsin L, researchers have suggested that it can reduce the drug resistance that can occur if the virus mutates. Even if the virus modifies the Mpro structure, it requires cathepsin L and vice versa.

IBD medicine COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears

SARS-CoV-2, COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears It causes a virus and uses a host protein called ACE2 to invade healthy cells. However, this protein is also usually involved in the inflammatory process. ACE2 is highly expressed not only in the lungs, but also in various other parts of the body, including the intestines.The novel is increasing the amount of evidence of the novel Coronavirus You can use the digestive tract (gastrointestinal) to enter somatic cells.

Based on these facts, researchers examined records of 1,000 patients at Cedars Sinai in St. Louis, Missouri, and several other centers in North America, and found Crohn’s disease and ulcerative colitis (two types of IBD). And non-IBD patients.

Inflammatory bowel disease is a group of disorders that cause long-term inflammation of the intestines, primarily the colon and rectum.

They found that ACE2 expression in the colon was increased in the case of IBD, and these increased levels were associated with poor people. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears result.

In both types of IBD patients, treatment with an anti-inflammatory drug called infliximab normalized and improved intestinal ACE2 levels. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears result.

However, the authors have shown that more research is needed to better understand the processes involving ACE2 and how to treat with ACE2. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears patient.

For more information COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears..

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