Health
Inflammation caused by a bacterial infection alerts brain stem cells
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A study supervised by Isabel Farinhas and published in a journal Cell stem cell Inflammation produced by a bacterial infection warns brain stem cells and reveals that they prepare their activation for the generation of new neurons. This study represents new advances in the field of regenerative medicine.
Tissue is constantly updated by the stem cell, Create new special cells to replace the cells lost due to wear. These stem cells are located in a very specific location within a tissue known as a microenvironment or niche, and the stem cells interact with other types of cells.
New discoveries show that brain stem cells also respond to changes that occur outside the brain. This study, conducted in mice, inflammation Generated by Bacterial infection Any part of the body can be temporarily activated Brain stem cells And prepare them for action. When the inflammation subsides, these cells return to a resting state. “This study gives us a better understanding of the relationship between stem cells and the systemic environment, the rest of the organism, because we have very limited knowledge of the subject. We are in the closest microenvironment. We are accustomed to responding stem cells, but we are beginning to show that we can react to what is happening in any part of the body, thanks to molecules distributed through the evidence circulatory system, “says Farinhas.
The research team’s work provides new data for research and advances in regenerative medicine, a field that seeks stem cell-based therapeutic solutions for degenerative processes such as Alzheimer’s disease and Parkinson’s disease, where neuroinflammation is usually detected.
“We have always been more worried Chronic inflammation It is associated with many diseases and is very negative for our organs, but it is a defense mechanism against injury and infection, “explains Jose Manuel Morante, co-director of the study.The role of inflammation in the regulation of Stem cells“He concludes.
Germán Belengueretal. Adult neural stem cells are warned by systemic inflammation through TNF-α receptor signaling. Cell stem cell (2020). DOI: 10.1016 / j.stem.2020.10.016
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