Health
Highly effective measles virus-based Th1 bias coronavirus vaccine
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Has been updated: December 1, 2020 08:26 IS
Washington [US], December 1st (ANI): Measles virus based COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears Vaccines may be able to prevent both COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears According to a new study, measles.
According to the author, measles virus based COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears The vaccine can be given as part of a regular measles vaccination schedule.
In a study published in the journal PNAS, researchers COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears Vaccine candidate based on the attenuated live measles virus.
SARS-CoV-2, The virus that causes COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appearsKills more than 1 million people worldwide, emphasizing the urgent need for effective vaccines.
Michael Muhlebach and colleagues explored the possibility of using the attenuated live measles virus as a vector for coronavirus vaccines.The author inserted the gene for SARS-CoV-2 Spikes proteins into the genome of measles virus strains used in measles vaccines.
The sera of mice or hamsters vaccinated with this recombinant virus contained antibodies that could be effectively neutralized. SARS-CoV-2 Measles virus.
Cytotoxic T cells from vaccinated mice selectively killed expressing cells SARS-CoV-2 Spike protein when stimulated with spike protein.
Antibody and cytokine levels in vaccinated mice are consistent with Th1-biased immune responses, suggesting a low risk of immunopathology such as enhanced antibody dependence and enhanced respiratory disease.
In hamster and mouse models, vaccinated animals had lower viral load and milder disease after infection. SARS-CoV-2 From unvaccinated animals. (ANI)
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