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The new antiviral drug Mornupyrabir claims to stop coronavirus infection in 24 hours

The new antiviral drug Mornupyrabir claims to stop coronavirus infection in 24 hours

 


Researchers COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears With the new antivirals MK-4482 / EIDD-2801 or Molnupiravir, the virus infection is completely suppressed within 24 hours. According to a study published in Nature Microbiology, a research team at Georgia State University (GSU) first discovered that the drug was potent against the flu virus.

“This is the first demonstration of an orally administrable drug to quickly stop SARS-CoV-2 infection. MK-4482 / EIDD-2801 may change the game,” said a GSU research author. One Richard Plemper said.

Because the drug can be taken orally, treatment can be started early and potentially triple the benefits. This means controlling the progression of the patient to serious illness, shortening the stage of infection and reducing the emotional and socio-economic burden of long-term patient isolation and rapid silence.

“MK-4482 / EIDD-2801 exhibits broad spectrum activity against respiratory RNA virus, and oral administration of infected animals with drugs reduces the amount of virus particles released by several orders of magnitude, dramatically reducing infection. We pointed out early on that it would decline, “Plumper said.

“These properties make MK-4482 / EIDD / 2801 a strong candidate for the pharmacological regulation of Covid-19,” Plemper added.

Meanwhile, decisions regarding the conduct of human experimentation with this drug will be made at a strategic group meeting of the Scientific and Industrial Research Council (CSIR). Dr. Shekhar Mande, Secretary-General of CSIR, believes this is an exciting development.

“A US researcher showed how ferrets blocked transmission. It was like any other anti-influenza drug and was immediately included in the list of drugs entering clinical trials. I’ll take it up. There will be a meeting tonight to make a decision, “Dr. Mande reportedly told the Indian newspaper.

In this study, the research team reused MK-4482 / EIDD-2801 for SARS-CoV-2 and used a ferret model to test the effectiveness of drugs that block the spread of the virus. The team considers ferrets to be a related model of infection because they easily spread SARS-CoV-2, but most often have severe illnesses that closely resemble SARS-CoV-2, which spreads to young adults. It does not develop.

Researchers infected ferrets with SARS-CoV-2 and began treatment with MK-4482 / EIDD-2801 when animals began releasing the virus through their noses.

“When infected animals were treated in the same cage with untreated contact ferrets, none of the contacts were infected,” said study co-author Joseph Wolff.

If these ferret-based data are converted to humans, drug-treated Covid-19 patients may become non-infectious within 24 hours of starting treatment.

“MK-4482 / EIDD-2801 is in advanced Phase II / III clinical trials for SARS-CoV-2 infection,” the authors write.

(There is input from the agency)

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