Health
COVID-19 Increases Stroke Risk, Studies Find Reasons
A study led by the University of California, Los Angeles (UCLA) used 3D-printed “blood vessels” to explain how the COVID-19 virus increases the risk of stroke.
Researchers studied running fluids spiked with COVID-19-like proteins through a 3D-printed model of the arteries of a stroke patient.
COVID-19 was first identified by its severe respiratory symptoms, but little is known about how the virus increases the risk of stroke.
To enhance the findings, UCLA researchers use a 3D-printed silicon model of blood vessels in the brain to push blood into an abnormally narrowed artery called intracranial atherosclerosis. Mimicked the force produced by. They showed that these forces act on the cells that line the arteries, increasing the production of a molecule called angiotensin converting enzyme 2 or ACE2, which the coronavirus uses to invade cells on the surface of blood vessels. ..
Dr. Jason Hinman, an assistant professor of neurology at UCLA’s School of Medicine and lead author of the study, argued that flow directly affects ACE2 expression.
In addition to Hinman, the authors of the study are neurologists at Geffen School of Medicine and scientists at the University of California, San Francisco and the Department of Veterans Health. This paper was published in Stroke (PDF).
UCLA researchers used data from CT scans of blood vessels in the human brain to create a model. The inner surface of the model was then lined with endothelial cells, the type of cells that line human blood vessels. The model allowed researchers to mimic the same forces that act on real blood vessels during COVID-19 infection.
To see if the coronavirus that sways along the bloodstream can latch into ACE2 in the endothelial cells of the brain, researchers have investigated the spiky protein-encrusted “virus” fat that the coronavirus uses to bind to ACE2. Generated a molecule. Previous studies have shown that the coronavirus binds to endothelial cells in other organs, but it was unclear if it was also occurring in the brain.
After creating the new model, researchers confirmed that the particles actually interact with the cells that line the blood vessels. It is primarily the area of the brain where ACE2 levels are high.
“This finding may explain the increased incidence of stroke seen with COVID-19 infections,” Hinman said.
Another finding is that when scientists analyze which genes are turned on in endothelial cells after the coronavirus spike protein binds to endothelial cells, the activated genes are found in certain immune responses in the cerebral blood vessels. It is a cell that indicates that it has been discovered to be a set of genes, but not in endothelial cells from other organs of the body.
“There is a unique cerebral endothelial response to the virus that can help identify patients at high risk of stroke,” Hinman said.
Researchers will follow up with live coronavirus in a 3D-printed vascular model. This further confirms the current findings and reveals which COVID-19 patients are at increased risk of stroke. (ANI)
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