The first study of this type recently investigated the association between the severity of COVID-19 and the gut flora. In the proposed research studies, specific microbial patterns associated with the severity of infection, and imbalances between those microorganisms, may be responsible for some outbreaks of “long COVID”.
according to New atlas More and more studies have reportedly found a link between the human immune system and large populations of intestinal microbes. This is called the intestinal flora.
The above reports identifying such associations suggest that the human microbiota may or may affect inflammatory activity in the body. Moreover, such relationships can play an important role in everything from depression and obesity to Alzheimer’s disease.
In light of these recent discoveries of the microbiome, it is realistic to think of the effects of gut flora, perhaps the biggest acute health problem of the time, with COVID-19 It may be characteristic of new gut flora. “
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A study showing the association between COVID-19 severity and gut flora examined blood and stool samples from 100 hospitalized patients compared to more than 75 healthy control subjects. ..
Unique bacterial composition
Studies have shown that COVID-19 patients have a unique bacterial composition compared to influenza and healthy regulated patients.
Another small early study examining only 15 cohorts suggested that changes in the microbial flora may correlate with the severity of COVID-19.
This new study BMJ journal IntestinesProvides a more detailed assessment of the association between COVID-19 severity and intestinal flora and common biomarkers of inflammation.
The study examined blood and stool samples from 100 patients trapped in hospitals compared to more than 75 healthy control subjects.
This study found substantial microbial differences between control subjects and COVID-19 patients. Species containing Bifidobacterium adolescentis, Faecalibacterium prausnitzii, and Eubacterium rectale were previously shown to play important roles in immune system activity, but were all observed in significantly lower doses in COVID-19 patients.
In addition, as shown in the study, COVID-29 patients also showed very high amounts of microbial species, including “Ruminococcus gnavus, Ruminococcus torque, and Bacteroides dolly”.
Signature of the destroyed microbial flora
A smaller subset of COVID-19 patients in the study were followed for up to 1 month from recovery and discharge, and the characteristics of the disrupted microbial flora appeared to persist outside the stage of acute disease.
One hypothesis raised by researchers is the destruction of the microbial flora. Prolonged symptoms COVID-19 patients may experience months after infection.
It should be noted that these findings are merely referrals and the causal relationship cannot be further understood.
For example, it remains unclear whether patients with these particular illnesses had irregular microbial flora characteristics prior to viral infection.
It is unclear whether these microbial flora features have a direct impact on the severity of the disease or simply the result.
Research author conclusions
Perhaps the most fascinating hypothesis from this initial study suggests that certain personalized microbiota treatments may be useful treatments for patients following the acute phase of the aforementioned infections. is.
Research studies have shown that the exogenous gut flora that persists after disease resolution may be a factor in developing “persistent symptoms and / or multisystem inflammatory syndrome” that occurs in some patients after removal of the virus. There is sex. “
Studies also show that gastrointestinal species enhancement COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears It emphasizes the importance of controlling gut flora in and after COVID-10 and may serve as a new opportunity to alleviate serious illness.
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