Health
Obesity can exacerbate the effects of Alzheimer’s disease, new studies show
A brain that can see all white matter tracts. The white matter tract is vulnerable to damage to people with uncontrolled cardiovascular risk such as obesity.Credit: University of Sheffield
Overweight can put additional strain on brain health and exacerbate Alzheimer’s disease, according to a new study from the University of Sheffield.
Pioneering multimodal neuroimaging studies show that obesity can contribute to nervous tissue fragility while maintaining a healthy weight in mild Alzheimer’s disease disease Dementia may help preserve Brain structure..
Survey results published in Journal of Alzheimer’s Disease Report, It also highlights the potential effects of overweight in middle age on the brain health of older people.
The lead author of this study, Professor Annalena Venneri of the Institute of Neuroscience at the University of Sheffield and the NIHR Sheffield Center for Biological Medicine, said: Research efforts do not yet have a cure for this cruel disease.
“Prevention plays a very important role in the fight against disease. It is important to emphasize that this study does not show that obesity causes Alzheimer’s disease, but overweight is an addition to brain health. It is a burden on the disease, which indicates that it can worsen brain health. “
She added: “Disease that causes dementia such as Alzheimer’s disease and Alzheimer’s disease Vascular dementia Having been in the background for years, it’s too late to wait for your 60s to lose weight.We need to start thinking Brain health And prevent these diseases much sooner. Educating children and adolescents about the burden of overweight on multiple diseases, including neurodegenerative diseases, is essential. “
Researchers at the University of Sheffield and the University of Eastern Finland examined MRI brain scans from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia. Mild cognitive impairment, And 57 cognitively healthy individuals.
In this new study, we used three complementary computational techniques to examine the anatomy of the brain, blood flow, and even brain fibers.
The international team compared multiple brain images and measured differences in local concentrations of brain tissue to assess the amount of gray matter denatured at the onset of Alzheimer’s disease.White matter integrity, brain Blood flow And obesity.
In patients with mild dementia, there was a positive association between obesity and grayish mass around the right temporoparietal junction. This suggests that obesity may contribute to neural fragility in cognitively healthy individuals and individuals with mild cognitive impairment.
The study also found that maintaining a healthy weight in mild Alzheimer’s disease dementia may help maintain brain structure in the presence of age- and disease-related weight loss. Did.
Dr. Matteo De Marco of the University of Sheffield Neurosciences Research Foundation, co-author of this study, said: -Grab foods such as biscuits and potato chips instead of more nutritious meals.
“We have found that maintaining a healthy weight can help maintain the brain structure of people who already have mild Alzheimer’s disease. dementia..Unlike other illnesses such as cardiovascular disease and diabetes, people rarely think about the importance of nutrition in relation to their neurological state, but these findings show that it helps preserve. brain Construction. ”
Manmohi D. Dake et al, Obesity and Brain Vulnerability in Normal and Abnormal Aging: Multimodal MRI Study, Journal of Alzheimer’s Disease Report (2021). DOI: 10.3233 / ADR-200267
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