Health
Obesity can affect a girl’s pubertal timing and hormones
Washington-Adolescents look different in girls with excess total fat, both in terms of reproductive hormones and breast maturity, according to a new study published in the Endocrine Society. Journal of Clinical Endocrinology & Metabolism..
Previous studies have found that obese girls begin puberty Experience the first menstruation earlier than a girl of normal weight. It is unclear whether excess body fat can alter not only pubertal timing, but also the reproductive hormone levels of girls and the development of reproductive organs such as the breast, ovaries, and uterus.
“From mid to late puberty, girls with high total body fat were found to have high levels of several reproductive hormones, including follicle-stimulating hormone (FSH), activin B, and male-like hormones such as testosterone. , Higher testosterone levels were associated with irregular menstrual cycles, acne, and excess hair, “said the National Institutes of Health (NIH) in Durham, NC” Late Adolescent, Fatty Girls Showed delayed breast maturation, and early puberty, as determined by breast ultrasound. There was no difference in ovarian or uterine maturation as a function of body fat.
The researchers studied 90 girls between the ages of 8 and 15 (36 obese and 54 with normal weight) over a four-year period. They use a dual-energy X-ray absorption assay (known as a DXA scan) to calculate total body fat, use Tanner staging to track puberty, and perform breast and pelvic ultrasound. Hormone levels in blood samples were then measured and the age at first tide of each girl was recorded. Researchers have found that girls with high total fat have different levels of reproductive hormones, mature breasts develop slowly, and the initial tide is faster than girls with low total fat.
“The long-term results of these differences in adolescent markers deserve further research,” Shaw said.
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Other authors of this study include Madison T. Ortega, Lauren Carlson, Vanessa Flores Pocha, Bob Z. San, Shanshan Chao, and Breana Beer from NIEHS. Social & Scientific Systems, Inc. in Durham, North Carolina. John A. McGrath, Gary Larson, Christian Douglas; Hubert W. Centers for Disease Control and Prevention in Atlanta, Georgia. Vesper, Lumi Duke, Julianne C. Botelho; Armand C. Philly of the NIH National Cancer Institute in Bethesda, Maryland.
The manuscript was funded by NIEHS.
Manuscript, “Longitudinal study of adolescent milestones and hormones as a function of girl’s body fat, ”Was published online before printing.
The author publishes related studies at Endo 2021, The annual meeting of the Endocrine Society.
Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health and hormone-related cancers. The Endocrine Society is the oldest and largest organization in the world of scientists dedicated to hormone research and doctors caring for people with hormone-related conditions.
The association has more than 18,000 members in 122 countries, including scientists, doctors, educators, nurses and students. For more information on academic societies and the fields of endocrinology, please visit: http: // www.
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