Health
COVID vaccine may not protect transplant recipients
New studies show that the COVID-19 vaccine may not work for organ transplant recipients.
When clinical trials were conducted to determine the immunogenicity (ability to elicit an immune response) of the first two vaccines marshalled against the COVID-19-causing virus SARS-CoV-2, 1 One group was not included: received solid organ transplantation and other immunodeficiency (such as those with autoimmune disease).
Currently, researchers at Johns Hopkins Medicine are the first to see how immunocompromised people respond to the first dose of Moderna and Pfizer-BioNTech, one of the two mRNA vaccines currently being administered worldwide. I investigated and tried to correct the injustice.
Their findings are Journal of American Medical AssociationUnfortunately, only 17% produced detectable antibodies against the SARS-CoV-2 virus.
“This is in stark contrast to people with a healthy immune system. vaccinationAlmost everyone has adequate antibody protection against COVID-19, “said Brian Boyarski, lead author of the study, a surgical trainee at Johns Hopkins University School of Medicine.
The study evaluated the vaccine immunogenicity response of 436 transplant recipients, but none had a pre-diagnosis of COVID-19 or tested positive for SARS-CoV-2 antibody. did. The median age was 55.9 years, with 61% being female. Of the participants, 52% received a single dose of the Pfizer-BioNTech vaccine and 48% received a single dose of the Moderna vaccine. The median time from transplantation for participants was 6.2 years.
At a median of 20 days after the first dose of the vaccine, researchers reported that only 76 (17%) of the 436 participants had detectable antibodies against the SARS-CoV-2 virus.Researchers also found that of the 76 transplant recipients, they were the most likely to develop an antibody response. young Over 60 years of age who have been vaccinated with Moderna vaccine without taking antimetabolites for immunosuppression.
“Based on these observations, the U.S. Center for Disease Control and Prevention is for vaccinated individuals to warn immunocompromised people that they may be susceptible to COVID-19 after vaccination. We believe we need to update our new guidelines. ”Director of the Epidemiology Research Group on Surgery and Epidemiology in Organ Transplantation at Johns Hopkins University School of Medicine. “People believe that vaccination means immunity, as the guidelines are currently written.”
Future studies will define the immunogenic response of organ transplant recipients and other immunocompromised patients after the second vaccination, Segev said. Other studies include broader immunity, including characterization of immune cells that memorize SARS-CoV-2 and produce antibodies after vaccination, and characterization of immune cells that directly attack the virus in response to the presence of the virus. Investigate the effects of system profiling and assist in vaccination guidance. Strategy for this population.
Source: Johns Hopkins University
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