Health
Blood pressure tablets should be given based on risk, not heart attack or stroke history.
According to the largest analysis ever on this issue, blood pressure tablets can prevent strokes and heart attacks even in healthy adults.
In a 345,000 study drawn from 48 randomized clinical trials, blood pressure-lowering drugs reduce the risk of serious cardiovascular events by about 10%, even in adults with normal blood pressure and no history of heart attack or stroke. I found out that I would let you.
Survey results, Released today at Lancet, Leading to a call from a researcher International Guidelines need to be changed so that doctors can consider prescribing medications to people at high risk of cardiovascular disease regardless of blood pressure.
Currently, dosing is limited to individuals with high blood pressure-usually 140/90 mmHg or higher.
Kazem Rahimi, Professor of Cardiovascular Medicine and Population health The lead author of research at Oxford University states: “Our findings are very important for discussions on blood pressure treatment.
“This new and best available evidence shows that the decision to prescribe a blood pressure drug should not simply be based on a pre-diagnosis of cardiovascular disease or an individual’s blood pressure level.
“Instead, drug therapy should be seen as an effective tool for preventing cardiovascular disease in people at high risk of developing heart disease and stroke. We have changed clinical guidelines to reflect these findings. need to do it.”
However, he emphasized that their conclusion does not mean that the drug should be prescribed universally.
“The decision depends on the individual’s risk factors for developing cardiovascular disease, the potential for side effects, and the choice of patient,” said Professor Rahimi.
Heart disease and stroke associated with high blood pressure Scotland Moral rates from cardiovascular disease have improved significantly in recent decades, but still remain about 22 percent higher than the UK average.
In Scotland, there have been more than 20,000 cardiovascular deaths since the beginning of 2020.
Although blood pressure medications are widely accepted to prevent people who have had a heart attack or stroke before, there is clear guidance on using these medications in people with normal or mild hypertension. there is no.
In Lancet’s study, participants were divided into two groups. There are 157,728 people with a history of cardiovascular disease and 186,988 people without cardiovascular disease.
The average age was 65 years.
Randomized trials from which data were drawn covered a variety of intervention types, such as drug-to-placebo, drug-to-drug, or more or less intensive treatment.
read more: The world’s first stroke study on the long-term effects of Covid on patients
Each group was then divided into 7 subgroups, from less than 120 to more than 170, based on the onset systolic blood pressure.
With an average of four years of follow-up, 42,324 participants experienced at least one major cardiovascular event, including heart attack, stroke, heart failure, and death from cardiovascular disease.
For every 5 units (mmHg) of decreased systolic blood pressure in participants, the risk of developing major cardiovascular disease is about 10%, stroke 13%, heart failure 13%, ischemic heart disease 8%, heart Deaths from vascular disease are 5%.
The beneficial effects of treatment did not differ based on the previous history of cardiovascular disease or blood pressure levels at the start of the study.
Co-author Zeinab Bidel said: “It is important to consider blood pressure lowering treatments based on cardiovascular risk, rather than focusing on blood pressure itself as a treatment eligibility factor or target.
“We need to provide comprehensive guidelines for reducing the risk of cardiovascular disease, including exercise, nutrition, smoking cessation, and, where appropriate, medication.”
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