Health
New Vaccine Block Covid-19, Variants and Other Coronaviruses | Global Indian
New York-American researchers have proven effective against the original SARS-CoV-1, SARS-CoV-2, and UK, South Africa, Brazilian variants, and associated bat coronavirus. New vaccine has been developed. The next pandemic.
A new vaccine, called the pancoronavirus vaccine, has been found to be effective in protecting monkeys and mice.
Pancoronavirus vaccine triggers neutralizing antibodies via nanoparticles. Nanoparticles are composed of coronavirus moieties that allow them to bind to cell receptors in the body and contain chemical boosters called adjuvants. Researchers at Duke University in North Carolina said success in primates is highly relevant to humans.
Findings published in Nature show that the monkey nanoparticle vaccine 100% blocked Covid-19 infection. The new vaccine also elicited significantly higher levels of neutralization in animals than current vaccine platforms or natural human infections.
“We started this work last spring, knowing that the SARS-CoV-2 virus, like all viruses, would mutate and produce Covid-19,” said the Duke Human Vaccine Institute. Director Barton F. Haynes, senior author, said.
“Because the mRNA vaccine was already under development, we were looking for a way to maintain its effectiveness after the emergence of these mutants. This approach not only provides protection against SARS-CoV-2, but also provides protection against SARS-CoV-2. Vaccine-induced antibodies originated in the United Kingdom, South Africa, and Brazil, and the induced antibodies reacted with a very large panel of coronaviruses, “Haines said.
The team was built on previous studies of SARS, a respiratory disease caused by the coronavirus called SARS-CoV-1. They found that people infected with SARS developed antibodies that could neutralize multiple coronaviruses. This suggests that pan-coronavirus may be possible.
They identified specific receptor-binding domain sites present in SARS-CoV-2, their circulating variants, and SARS-related bat viruses that are highly vulnerable to cross-neutralizing antibodies.
The team then designed nanoparticles to display this vulnerable spot. Nanoparticles are combined with small molecule adjuvants to boost the body’s immune response to combat disease.
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