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Covid pandemic: Why Indonesia has become a testing ground for the Chinese Covid-19 vaccine

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A voluntary vaccine is drawn in blood at a clinic in Bandung, West Java, on September 11.

Photographer: Dimas Ardian / Bloomberg

On a hot August day in Bandung, the capital of West Java province, two dozen volunteers arrive at a small community clinic inside a narrow lane to participate in the final leg of one of the trials. the fastest in the world for acoronavirus vaccine.

There, surrounded by cramped houses and children playing outside without masks, they prepare to take an experimental photo developed by China.Sinovac Biotech Ltd., many of whom in Indonesia hope will end the destruction caused by the virus. With around a quarter of a million infections, Indonesia’s outbreak is Southeast Asia’s second worst after the Philippines, with its daily number of cases hitting record highs every week since the end of August.

New Covid-19 boxes

Seven day average

Data: Johns Hopkins University

“I am tired of how we deal with this disease. I just want to help in any way I can, ”says 27-year-old microbiologist Abinubli Tariswafi Mawarid, one of the volunteers. “I believe the vaccine is the miracle solution to solving this pandemic. This is the most appropriate solution. “

Few countries have embraced the possibility of a vaccine with as much fervor as Indonesia, where the government predicts the pandemic will push 4.9 million more people into poverty, weighing heavily on its population of around 270 million. ‘inhabitants. The country offers insight into the outsized expectations that are driving rapid development of Covid-19 vaccines globally – as well as potential pitfalls – as entire countries seek a quick fix.

Concerns Why Indonesia has become a proving ground for a Chinese Covid-19 vaccine

Vaccine volunteers wait to register for a health test at a clinic at Padjadjaran University in Bandung.

Photographer: Dimas Ardian / Bloomberg

In Bandung, a resort area of ​​more than 2 million people, clinical trials led by a state-owned pharmaceutical companyPT Bio Farma, were accompanied with great fanfare. Many of the 1,620 people from Bandung and neighboring towns who registered for the Sinovac trial have been interviewed in local media. The region’s police chief received an injection (which could have been the trial vaccine or a placebo), as did his governor, who promoted the experiment on Instagram. Bio Farma has worked with regulators to speed up approval of the Sinovac vaccine. He says he will manufacture 10 to 20 million doses before even getting the green light, so the vaccine will be immediately available.

Iin Susanti, head of planning and business strategy at Bio Farma, says wider distribution will not begin until after Indonesian regulators give emergency approval. President Joko Widodo has said his government is aiming for such a clearance for CoronaVac, as it is known, by January. The first batches will go to health workers.

Yet despite all the local hype, this help is at hand to finally tame the virus, which hasinfected 29 million people worldwide, it is not known for sure when a successful shot will be available. Health experts warn of the safety risks if speed is not carefully balanced, and little is known about the effectiveness of any inoculation. The risk of unexpected delays became apparent after theAstraZeneca Plchas halted testing of its experimental vaccine – considered one of the most promising in the world – over concerns over a participant who fell ill. The company has sincerestarted testing in the UK after regulators said it was safe to do so.

Concerns Why Indonesia has become a proving ground for a Chinese Covid-19 vaccine

View of dense housing under the Pasupati Bridge in Bandung. A poster by President Widodo promotes the wearing of masks.

Photographer: Dimas Ardian / Bloomberg

Global delays in the search for an effective vaccine would be devastating for countries that have staked heavily on a vaccine. Indonesia, for example, has a large informal workforce that risks starving to death during lockdowns. Its economy contracted 5.32% in the second quarter from a year earlier, the strongest since the aftermath of the Asian financial crisis in the late 1990s. The government briefly relaxed social distancing rules , but infections have increased. There are fears that Jakarta, the capital, may run out of hospital beds. The city has restricted the use of public transport and required non-essential industries for people to work from home.

“The physical distancing protocol will continue. But ultimately, the vaccine is the answer to ending this pandemic, “Jokowi, as the president is popularly called, to a group of foreign reporters in his palace on September 1.” There is no any other way I know of. . But even he acknowledged the uncertainties, pointing out that it is still not known how long the protective effects of a vaccine will last.

CoronaVac is also in trial phase III in Brazil and other parts of the world. (Late-stage trials require large numbers of participants in a location where the epidemic is active. This is not possible in China, which has largely eliminated local transmission.) Made using an inactivated version virus, CoronaVac is neck and neck with other global brands, including the vaccineModerna Inc., in its pace of development.

Jokowi’s administration also tasked local research institutes and universities to develop the country’s vaccine, dubbed “the red-white vaccine” after the colors of the Indonesian flag, by mid-2021. The most large pharmaceutical company in Indonesia,PT Kalbe Farma, has partnered with South Korean biotechnologyGenexine Co. and will begin phase II clinical trials in November, which measure a drug’s effectiveness and short-term risks.

Balancing safety and speed remains a challenge. The rate at which companies around the world are rushing into clinical studies to administer a vaccine against the coronavirus is unprecedented. Vaccine development, which can normally take up to a decade, is being cut to less than a year by drug makers, leaving some researchers concerned about the lack of time to fully understand the potential risks that any vaccine could. present.

LOWER LINE –
With a large informal workforce that cannot be confined to their homes, Indonesia is eager to get vaccinated against the coronavirus. But with 6,000 inhabited islands, distributing one will be difficult.

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