College football odds, picks, lines, bets, predictions for week 6, 2024: computer model backs Iowa, California

Michigan and Washington will meet in a rematch of last year's National Championship Game in one of the best matchups on the Week 6 college football schedule. The programs may also be in the early stages of a rivalry, with Washington this year makes his Big Ten debut. Washington is 3-2, including 1-1 in the Big Ten, under Jedd Fisch, who coached at Arizona last season. Michigan is 4-1 (2-0 Big Ten) under Sherrone Moore, who was part of the Wolverines' staff last season. Washington is a 2.5-point favorite at home, up a half-point from the opener, according to the latest Week 6 college football odds from the SportsLine consensus.

Washington has won seventeen straight home games since the start of the 2022 college football season, so how would that impact your college football betting in a Week 6 college football schedule that also includes matchups like No. 9 Missouri (+ 2.5) against No. 25 Texas A&M? Before you commit to a Week 6 college football pick for that or any other games, Be sure to check out the latest college football predictions based on SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated over $2,000 in winnings for $100 players on the top-rated university spread football picks. It also went a blistering 6-0 on all top-rated college football picks in Week 5. Anyone who's been following has seen strong returns.

Now it has turned its attention to the latest college football opportunitiesand week 6 college football betting on the spread, moneyline and over/under.Go here to see every choice.

The best college football predictions for week 6

One of the college picks the model is high on during Week 6: Iowa (+19.5) stays within the wide spread at No. 3 Ohio State in a 3:30 PM ET matchup on Saturday on CBS. The Buckeyes opted to play a weak non-conference schedule this season, facing no real opposition through the first three weeks of the campaign. They opened conference play with a comfortable win over Michigan State, but will face a better opponent on Saturday.

Iowa is coming off its best performance of the season, heading to a 31-14 win at Minnesota as a 2.5-point favorite. Junior running back Kaleb Johnson continued his phenomenal start, racking up 206 rushing yards and three touchdowns on 21 carries. He's racked up at least 119 rushing yards and two touchdowns in every game this season, and he's a big reason why the model has Iowa covering the spread in well over 50% of simulations. Check out the rest of Week 6's college football picks here.

Another prediction: California (+10.5) will play a one-score game against No. 8 Miami on Saturday in a 10:30 PM ET kickoff. Cal takes its first loss of the season, falling to Florida State and dropping to 3-1. Saturday will mark the second time the Golden Bears have been double-digit underdogs, having defeated Auburn 21-14 on Sept. 7 as 12-point underdogs. The Bears have performed well as underdogs at home in recent seasons, but with a 6-2-1 ATS record in those scenarios since the start of the 2020 college football season.

Cal has one of the best defenses in the country, holding opponents to 12.7 points per game, which ranks ninth in college football. Defensive back Nohl Williams has four interceptions in four games and linebacker Teddye Buchanan has 40 tackles, including 2.5 sacks, to lead the stout defense. This is a key reason why Cal covers the spread in 60% of simulations.Check out the picks for every other game in Week 6 here.

How to Make College Football Picks for Week 6

The model also made a call on who will win and cover in each FBS matchup in Week 6, calling for as many as seven underdogs to win outright, including an upset in one of the biggest games of the week.You can only get every pick for every game at SportsLine.

So which college football picks can you make with confidence, and which seven underdogs win outright in Week 6? Then check out the latest college football odds below visit SportsLine to see which teams are winning and cover the spread, all from a proven computer model that has generated over $2,000 in profits since its inceptionand find out.

College Football Odds for Week 6

Get the full college football picks, odds and predictions from Week 6 here

Thursday October 3

State of Texas at Troy (+13.5, 57.5)

Sam Houston State at UTEP (+10.5, 50)

Friday October 4

Jacksonville State and Kennesaw State (+16.5, 48.5)

Houston at TCU (-16.5, 51.5)

Syracuse at UNLV (-6.5, 58.5)

Michigan State at Oregon (-24, 52.5)

Saturday October 5

Missouri at Texas A&M (-2.5, 48.5)

UCLA at Penn State (-28, 46.5)

Auburn in Georgia (-24.5, 52.5)

Ole Miss at South Carolina (+9.5, 53.5)

Iowa at Ohio State (-19.5, 45.5)

Alabama at Vanderbilt (+23.5, 55.5)

Clemson at Florida State (+14.5, 48)

Tennessee at Arkansas (+13.5, 59.5)

Baylor at Iowa State (-11.5, 44.5)

USC at Minnesota (+8.5, 51.5)

Michigan at Washington (-2.5, 41.5)

Miami in California (+10.5, 55)

Texas Tech at Arizona (-6.5, 64)