Alnylam, a leading RNA cross-reference (RNAi) therapist, is welcomed as the latest partner in the Medicines Manufacturing Innovation Center to transform the manufacturing process of oligonucleotide therapies.
The Center for Pharmaceutical Manufacturing Innovation is a collaboration between CPI, the University of Strathclyde, UK Research & Innovation, Scottish Enterprise, and its founding partners, AstraZeneca and GSK.
Alnylam is a US-based company founded in 2002 that has since established leadership in RNAi and has an extensive portfolio of oligonucleotide therapies on the market.
The company will work with CPI, Novartis, AstraZeneca and Exakumar, a deep tech innovation organization. This industry collaboration also solves several complex challenges associated with manufacturing these therapies, including sustainability, cost, and scalability issues.
Oligonucleotides are synthetic fragments of chemically modified RNA or DNA that can modify the expression of proteins associated with a variety of diseases. Although these treatments have already been approved for use in certain rare hereditary disorders, they have great potential for the treatment of chronic disorders such as spinal muscular atrophy, Alzheimer’s disease and hypertension.
Dave Tudor, Managing Director of CPI’s Center for Pharmaceutical Manufacturing Innovation, said: This partnership complements Grand Challenge 3’s expertise and enables projects to be delivered more efficiently, resulting in faster delivery of solutions to the pharmaceutical market. “
Al Boyle, Chief Technical Operations and Quality Officer at Alnylam, said: “The goal of this Grand Challenge to revolutionize the manufacturing process of oligonucleotide therapy is critical to the future of medicine. The success of this Grand Challenge advances innovators to the wider patient population of oligonucleotide therapies. Helps to enable sustainable production on a larger scale and at lower cost. “
The oligonucleotide therapeutic market is expected to be worth about $ 7.23 billion by 2024.
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