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Q & A: Improvement of cell delivery by Abcam



Med-Tech Innovation editor Ian Bolland tells life sciences supplier Abcam about the company’s latest efforts to develop new cell delivery solutions that have the potential to improve therapeutic survival of molecules. I will. How does your delivery method accommodate the growing number of complex medicines such as biologics?

Abcam works closely with Soma Serve, a spin-out of the University College London with deep expertise in cell delivery solutions. SomaServe uses a unique technology called PolyNaut to image living cells to improve therapeutic survival of molecules with poor pharmacokinetics and chemistry. PolyNaut technology is a versatile nanoengineered polymer technology for intracellular delivery in vivo. The resulting polymer nanoparticles vesicles are known as bionic nanoparticles. The wide variety of polymer structures is extremely flexible and can accept small molecules, peptides, proteins, antibodies, nuclear materials, dyes and probes. The resulting nanoparticles deliver those cargoes inside the cell, greatly enhancing the therapeutic effect of the encapsulated molecule. In addition, targeting ligands can functionalize the surface of vesicles to help penetrate biological barriers such as the blood-brain barrier. This cell delivery technology can also be successfully used to enhance live cell imaging, an early application of the SomaServe / Abcam partnership.

In addition to this, Abcam offers several key technologies that support scientists across the translational spectrum, from basic life science research to the development of complex medicines such as diagnostics and biologics. doing. Many of the scientists we support may be due to faster, more accurate, or new and innovative diagnostics and stratified regimes, or the development of treatments for conditions such as cancer and neurodegenerative diseases. The focus is on helping to address unmet clinical needs. From the early to late stages of development, Abcam has the technical expertise and capabilities to support innovative scientific discoveries while maintaining consistent quality and performance standards. Our custom solution products are particularly well suited to this approach, leveraging our in-house capabilities and expertise to create customized and flexible solutions for reagent generation, validation screens, custom assays, ISO standard manufacturing, and more. To provide.

What are the new or different areas of your partnership with SomaServe?

The first application of the partnership with SomaServe focuses on research applications, especially live cell imaging. Live cell imaging gives researchers a deeper understanding of pathology because it allows them to observe cell structure and processes in a dynamic way, far beyond what is possible in the study of fixed cells. The comprehensive partnership with SomaServe aims to revolutionize the development of new delivery methods and the use of live cell imaging to explore disease pathways. In addition, we are also exploring further applications to deliver a wider range of macromolecules to living cells.

What is the range of payload that nanoparticles carry to living cells?

The first focus of our partnership is to develop and commercialize a new range of CelLuminate fluorescent dyes for live cell imaging applications that offer clear advantages over other staining systems on the market. First and foremost, SomaServes nanoparticles are made by the automatic assembly of amphipathic GRAS (generally recognized as safe) copolymers that are non-toxic to cells. This allows for a longer observation period, with the cells viable for 14 days while still stained. In addition, since there are no chemical solvents involved in dye solubilization, staining with CelLuminate dye does not interfere with cell metabolism and provides a clearer picture of the staining process. Finally, SomaServes nanoparticles are absorbed via endocytosis and therefore have the ability to target a wide range of cells. This is a natural process common to many types of cells.

In addition to live cell imaging, we are exploring a wider range of applications using technologies to deliver a wider range of payloads, including antibodies, proteins, peptides, and nucleic acids.

How will your research and diagnostic development affect the pharmaceutical and biotechnology industries?

Beyond its partnership with SomaServe and its early research applications, Abcam is working hard to support the development of research and diagnostics in pharmaceutical and biotechnology. In addition to providing best-in-class validated recombinant rabbit monoclonal antibody (RabMAbs), the material employs a gold standard test approach, such as a target knockout (KO) cell line, to ultimately confirm specificity. We will also focus on verification and data reproducibility. This provides a tool with minimal inter-batch variability and a well-validated target binding profile, allowing customers and partners to do internal singularity testing and batch-to-batch comparisons without wasting time. You can concentrate on your development work. We also offer immunoassays on various plexes (Simple Step Elisa and FirePlex kits). They are highly regarded by pharmaceutical and biotechnology customers, especially for their simplicity, sensitivity and reproducibility, and help streamline and accelerate in-house R & D operations. Finally, it is important to note that our reagents are also available through partnerships in a wide range of research and diagnostic platforms.

It usually takes about 4 months to develop a KO cell line that validates the reagents. The acquisition of an extensive portfolio of CRISPR KO cell lines from Edigene, coupled with an in-house new gene editing platform and oncology-focused editing cell lines from the acquisition of Applied StemCell, is a broad range of these key reagents. We provide a wide range of portfolios. off the shelf. We are committed to getting ready-made cell lines with the desired KO in the right background to give the community freedom and flexibility and support accelerated R & D.

Which therapeutic area does your job cover?

Our core products have been developed for the research market and to provide them, we have established deep expertise and understanding of disease pathways in many key areas such as immuno-oncology, neuroscience and epigenetics. doing. In parallel, our custom solutions team provides expert development services to organizations developing diagnostics, prognostics, and therapies. These programs cover a wide range of therapeutic areas.

What benefits can you expect from the SomaServe partnership to improve drug delivery?

While the partnership with SomaServe focuses on live cell imaging solutions, its sister company, SomaNautix, is developing innovative nanoparticle-based therapies for the treatment of brain tumors. Beyond our ongoing collaboration with SomaServe, we have invested in their technology. Because we believe that their cell delivery technology has the potential to transform oncology.

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