Due to the lack of approved and effective treatment for COVID-19, some hospitals treat patients with severe COVID symptoms with plasma from recovering patients. The blood of recovered patients contains antibodies that act against the coronavirus. Plasma has not yet shown any benefit in randomized trials, but some small retrospective studies suggest that plasma may reduce the severity of the disease and reduce hospital stays. ..
This week, in mBio, an open-access journal of the American Society of Microbiology, researchers found that antibody levels in the blood of COVID-19 patients dropped rapidly in the weeks following the body’s removal of the virus and the symptoms subsided. I am reporting that. If convalescent plasma is shown to ultimately provide a clear benefit, the authors should conclude and collect it during a specific period after recovery. However, recovering patients cannot donate blood for at least 14 days after their symptoms have subsided, giving the body time to remove the viral particles.
“We don’t transfuse viruses, we just transfuse antibodies,” said Dr. Andrés Finzi of the University of Montreal, Canada. “But at the same time, our research shows that plasma’s ability to neutralize viral particles has diminished in the first few weeks.”
The SARS-CoV-2 spike protein plays an important role in helping the virus grab and invade the host cell. Antibodies produced by the body’s immune system bind to parts of this protein, blocking the ability of this “key” to participate in the “lock” of the host’s cells and preventing viral particles from infecting the cell host. I will.
Previous studies have suggested that antibodies to the SARS-CoV-2 spike protein peak 2-3 weeks after the onset of symptoms. Findings from a previous cross-sectional study by Finzi’s group of more than 100 patients found that the ability of plasma to neutralize the virus was significantly reduced between 3 and 6 weeks after the onset of symptoms. Suggested.
In a new longitudinal study, Finzi and his colleagues analyzed blood samples collected at monthly intervals from 31 individuals who recovered from COVID-19. They measured the level of immunoglobulins acting on the coronavirus S protein and tested the ability of antibodies to neutralize the virus.
The researchers observed fluctuations in individual patient levels, but identified a consistent overall signal. Levels of immunoglobulins G, A, and M targeting the binding site decreased 6-10 weeks after the onset of symptoms. At the same time, the ability of antibodies to neutralize the virus also declined.
Finzi’s group continues to study blood samples from patients. How antibody levels change over time not only to optimize the use of plasma during the convalescent period, but also to understand the effectiveness of the vaccine and whether previously infected people are at risk of reinfection. He said it was important to understand what to do.
“How much do antibodies protect you?” He asked.
Other Finzi studies have focused on the immune response to the human immunodeficiency virus (HIV), which is dramatically different from SARS-CoV-2.
See also: Guillaume Beaudoin-Bussières, Annemarie Laumaea, Sai Priya Anand, Jérémie Prévost, Romain Gasser, Guillaume Goyette, Halima Medjahed, Josée Perreault, Tony Tremblay, Anto’s “decreased humoral response to SARS-CoV-2 spikes in convalescent individuals” Lewin, Laurie Gokool, Chantal Morrisseau, Philippe Bégin, Cécile Tremblay, Valérie Martel-Laferrière, Daniel E. Kaufmann, Jonathan Richard, Renée Bazin, Andrés Finzi, October 16, 2020, mBio.DOI: 10.1128 / mBio.
ASM uses the COVID-19 Research Registry, a top-ranked research article curated by experts, to keep track of the SARS-CoV-2 pandemic. From a pandemic point of view, this carefully selected database allows scientists, journalists, and the general public to study the most timely and most valuable SARS-CoV-2 / COVID-19 studies from the latest journal articles and preprints. Ensure an efficient way to find.
The American Society for Microbiology is one of the largest specialized societies in life sciences, consisting of 30,000 scientists and healthcare professionals. ASM’s mission is to promote and advance microbial science.
ASM advances microbial science through conferences, publications, certifications and educational opportunities. Strengthen the capabilities of laboratories around the world through training and resources. We provide a network for scientists in academia, industry and clinical practice. In addition, ASM promotes a deeper understanding of microbial science to a diverse audience.
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