Former Principia team looks to shake covalently small molecules again, this time at the ‘quake scale’ – Endpoints News

The history of Terremoto Biosciences goes back nearly ten years, when University of California, San Francisco professor Jack Taunton founded Principia Biopharma. Peter Thompson initially led biotechnology.

The company has helped expand covalent small molecule inhibitors beyond oncology and autoimmune diseases by targeting cysteine. But this amino acid is uncommon in many proteins, and offers fewer pharmacological targets than, say, lysine, which is found in most proteins of interest. So, over the years, Taunton has come back to the drawing board to check out that second amino acid.

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