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WHO prequalifies new dengue vaccine
On May 10, 2024, the World Health Organization (WHO) prequalified a new dengue vaccine. TAK-003 is the second dengue vaccine to be prequalified by the WHO. Developed by Takeda, it is a live attenuated vaccine that contains weakened versions of the four serotypes of the virus that cause dengue.
WHO recommends the use of TAK-003 in children aged 6 to 16 years in settings with a high burden and intensity of dengue transmission. The vaccine should be administered according to a schedule of 2 doses with an interval of 3 months between doses.
“The prequalification of TAK-003 is an important step in expanding global access to dengue vaccines, as it is now eligible for procurement by UN agencies, including UNICEF and PAHO,” said Dr. Rogerio Gaspar, WHO Director for Regulation and prequalification. “With only two dengue vaccines prequalified to date, we look forward to more vaccine developers coming forward for evaluation to ensure vaccines reach all communities in need.”
The WHO prequalification list also includes the CYD-TDV dengue vaccine developed by Sanofi Pasteur.
Dengue is a vector-borne disease transmitted by the bite of an infected mosquito. Severe dengue is a potentially fatal complication that can develop from dengue infections.
It is estimated that there are over 100-400 million cases of dengue worldwide each year and that 3.8 billion people live in dengue-endemic countries, most of which are in Asia, Africa and the Americas. The highest number of dengue cases reported was in 2023, with the WHO Region of the Americas reporting 4.5 million cases and 2,300 deaths. Dengue cases are likely to increase and spread geographically due to climate change and urbanization.
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