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WHO is launching a global framework to understand the origins of new or re-emerging pathogens
With the support of the Scientific Advisory Group on the Origin of Emerging Pathogens (SAGO), the World Health Organization (WHO) published global framework help Member States to comprehensively investigate the origins of new and re-emerging pathogens. Although there are a number of tools available for investigating infectious disease outbreaks, this is the first unified, structured approach to investigating the origins of a new pathogen. This framework aims to fill that gap by providing a comprehensive set of scientific research and studies. It is the first version of a “how to” guide that will be updated as needed, based on user feedback.
As every epidemic and pandemic shows, human and animal health is threatened by the increasing risk of the emergence of known (such as Ebola, Nipah, avian influenza, Lassa and Monkeypox viruses) and new pathogens with epidemic and pandemic potential (new influenza, MERS-CoV , SARS-CoV-1, SARS-CoV-2), the ability to prevent, and when we cannot prevent, to quickly contain epidemics and identify their origins is scientifically, morally and financially more important than ever.
The WHO Global Framework lists scientific research and studies for six technical elements:
- Early research of the first identified cases/clusters/outbreaks to identify potential sources of exposure, collect samples at the source, define the characteristics of the new pathogen involved to establish diagnostic tests.
- Human research: understand the epidemiology including clinical presentation, modes of transmission, pathology and earliest presence in follow-up samples of the syndrome.
- The human/animal interface studies to identify potential animal reservoirs, intermediate hosts and reverse zoonoses.
- studies to identify insect vectors or other sources of infection as well as the earliest presence in the environment. …
- Genomics and phylogenetics studies to identify precursor strains, genomic characteristics, evolution of intermediate hosts and humans, and spatial distribution over time.
- Biosafety/biosafety studies to determine whether violations of laboratory or research activities may have been related to the first cases.
The WHO Global Framework is designed as a resource for scientists, researchers, public health authorities and researchers in Member States. It provides guidance on when and how to launch such multidisciplinary research and offers recommendations to countries on the capacities and tools needed for their successful implementation. This includes necessary capacities such as human resources, human, animal and environmental monitoring systems; biosafety and biosecurity regulations; and laboratories with testing and sequencing expertise – and the importance of sharing the findings of such research as soon as possible to guide next steps. These recommendations have been developed to align with the International Health Regulations (IHR) and use the One Health approach.
Timely and comprehensive research into the origin of pathogens is essential to prevent and contain global health crises. Findings from such research provide the basis for stopping disease outbreaks before they start, halting chains of transmission and reducing the risk of pathogens spilling over from animals to humans. They can also confirm or rule out the possibility of inadvertent breaches of laboratory biosafety and biosecurity.
To achieve this, it is critical that countries carry out these exchanges of initial findings in a rapid, complete and transparent manner as soon as the results are available to ensure the implementation of measures to mitigate further transmission and prevent further spillovers and, possibly, future pandemics.
“Understanding when, where, how and why epidemics and pandemics start is both a scientific imperative, in order to prevent future epidemics, and a moral imperative for the well-being of those who have lost their lives because of them,” said Dr. Tedros Adhanom Ghebreyesus, Director of the WHO- and. General. “This framework provides, for the first time, comprehensive guidance on the studies needed to investigate the origins of emerging and emerging pathogens. Had it existed when COVID-19 broke out, the quest to understand its origins might have been less contentious and more successful. WHO continues to urge China to share any information it has on the origin of COVID-19, so that all hypotheses can be investigated.”
Founded in November 2021 and composed of independent experts from around the world, SAGO was tasked with identifying the best technical and scientific approaches to understanding the origins of re-emerging pathogens and developing this global framework. SAGO is part of an enhanced emergency preparedness and prevention system developed by WHO, its member states and many health and scientific partners.
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