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providing free pediatric medicine can improve diagnosis and treatment
The documentation that gives the World Health Organization (WHO) a basic antiparasitic medicine for the treatment of Chagas disease is in the final stages of preparation.
A three-year contract between the Mundo Sano Foundation1 (Brazil) and WHO, it is expected that 108,000 tablets for the pediatric formulation of benznidazole will be available2 – a first-line remedy for Chagas disease. cure3 benzendazole in the early stages of infection can cure Chagas disease.
“Making benznidazole available for free in the treatment of infants up to the age of 18 will be a player change in the fight against Chagas disease” said Dr. Mwelece Ntuli Malecela, Director, World Health Organization Neglected Tropics Control Division
Disease. “This will not only save future generations from developing dangerous and life-threatening complications, but will also encourage diagnosis and treatment. “
Each year, about 15,000 children are born to infected mothers. A freely available pediatric dose of benznidazole with the correct doses is expected to contribute to the treatment of congenital infections.
“The treatment of infants and children has been a missing link, as we are committed to integrating the diagnosis of childhood and childhood infections into other surveillance programs, including HIV and syphilis.” said Dr. Pedro Albajar Vinas, a doctor at the WHO Department of Tropical Neglect Control. “Diagnosing and treating women of this age group before pregnancy can effectively promote congenital transmission“.
A grant from the Mundo Sano Foundation for the duration of the agreement contains benznidazole:
- 105,000 100mg tablets
- 3,000 12.5mg tablets
In addition, the Foundation may donate up to $ 100,000 for the duration of the agreement to support drug distribution activities and meetings. The Foundation also envisages extending this agreement beyond that agreement
a fixed duration of three years.
Disease
Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening disease caused by a protozoan parasite Trypanosoma cruzi (T. cruzi).
Although significant progress has been made, especially in reducing vector transmission and screening blood and organ supplies, the challenge is reaching and diagnosing the people who are most affected.
Currently, under-diagnosis of Chagas disease cases is as high as 90%, and it is believed that under-diagnosis of congenital transmission is even greater.
Globally, about 6-7 million people are infected T. cruzi.
The disease is found mainly in endemic areas of 21 continental Latin American countries4, But the movement of people to urban areas and to other continents has expanded its transmission to non-vector routes, such as blood transfusions, congenital
transmission, organ transplantation and oral contamination of food.
Considering the disease as a growing public health problem in many countries, the World Health Assembly – the WHO’s decision-making body – decided in May 2019 to mark World Chagas Disease Day on 14 April.
The inaugural celebration is happening this year.
1 Mundo Sano is a non-profit international foundation that collaborates with the public and private sectors, academia and other international organizations to provide solutions to affected communities and to generate scientific knowledge. In 2012, he led a public-private consortium for the production of benznidazole in Argentina.
2 In 2017, the U.S. Food and Drug Administration (FDA) approved benznidazole to treat children ages 2 to 12, making it the first U.S.-approved treatment for Chagas disease.
3 Nifurtimox is also 100% effective in treating Chagas disease if given shortly after the onset of infection, including cases of congenital infection. It is donated by Bayer, who has stocked more than 7.5 million tablets for 2012-2021.
4 Argentina, Belize, Bolivia (multinational country), Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Suriname, Uruguay and Venezuela
(Bolivian Republic).
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